{"id":"W2182810163","doi":"10.18632/oncoscience.102","title":"Selumetinib produces a central core of apoptosis in breast cancer bone metastases in mice","year":2014,"lang":"en","type":"article","venue":"Oncoscience","topic":"Bone health and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Alberta Cancer Foundation","keywords":"Selumetinib; Apoptosis; Cancer research; Breast cancer; KRAS; Medicine; Cancer; MEK inhibitor; Internal medicine; Biology; MAPK/ERK pathway; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003495659,0.00008988572,0.0002809938,0.0001350711,0.00002535718,0.000004414155,0.00007244596,0.00003023192,0.00003365783],"category_scores_gemma":[0.0001167432,0.00006939103,0.00002667198,0.0006340078,0.0001116633,0.00008524587,0.00002113618,0.00008993849,0.000004999862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001081556,"about_ca_system_score_gemma":0.0002821573,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009067294,"about_ca_topic_score_gemma":0.002007487,"domain_scores_codex":[0.9988406,0.00004063615,0.0002522471,0.0002757846,0.0002374771,0.0003531979],"domain_scores_gemma":[0.9995237,0.00004638724,0.00009132253,0.0001493704,0.00004232642,0.000146909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001820703,0.0006511214,0.9591942,0.0001382537,0.000004442652,0.000008399095,0.0003743768,0.00001091001,0.01372299,0.00006835917,0.0001654685,0.0254794],"study_design_scores_gemma":[0.001648311,0.0001683534,0.9828133,0.0002912953,0.00002361244,0.0000268697,0.00007125559,0.0003659663,0.01388996,0.000025683,0.000602153,0.00007321857],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968415,0.0002437722,0.000005265617,0.002058344,0.0001188709,0.0002804439,0.00002784382,0.00001023341,0.0004137643],"genre_scores_gemma":[0.9985029,0.0001288101,0.000780551,0.0003935213,0.00002062329,0.00003807143,0.000004217335,0.000005490402,0.0001258115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02540618,"threshold_uncertainty_score":0.9975314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02851456333532742,"score_gpt":0.3281677859478988,"score_spread":0.2996532226125714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}