{"id":"W2182810163","doi":"10.18632/oncoscience.102","title":"Selumetinib produces a central core of apoptosis in breast cancer bone metastases in mice","year":2014,"lang":"en","type":"article","venue":"Oncoscience","topic":"Bone health and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Alberta Cancer Foundation","keywords":"Selumetinib; Apoptosis; Cancer research; Breast cancer; KRAS; Medicine; Cancer; MEK inhibitor; Internal medicine; Biology; MAPK/ERK pathway; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003820577,0.0008365401,0.0006453924,0.001288996,0.000378661,0.0005777777,0.0005600757,0.0009268581,0.003301112],"category_scores_gemma":[0.0002066406,0.0004682147,0.0006272736,0.000373412,0.0004868479,0.0003791418,0.0003444193,0.002121756,0.0007020677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007270998,"about_ca_system_score_gemma":0.000413361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009680759,"about_ca_topic_score_gemma":0.002474184,"domain_scores_codex":[0.9995185,0.00007044518,0.00003669862,0.0001053896,0.0001387109,0.0001302464],"domain_scores_gemma":[0.9997322,0.00003325178,0.00007128822,0.00003754555,0.00002397031,0.000101727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001265434,0.0003605226,0.0002328325,0.00005812253,0.0000218063,0.0001010125,0.00004128397,0.0002018707,0.9935296,0.0004538594,0.0002386906,0.003494967],"study_design_scores_gemma":[0.0002662637,0.002947469,0.002514953,0.00001974725,0.00003593443,0.0003732122,0.0000429625,0.001390279,0.9878037,0.0002404183,0.004353981,0.00001115021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771564,0.003087673,0.007868518,0.0009730863,0.0002092507,0.0003163623,0.002769362,0.0006824099,0.00693698],"genre_scores_gemma":[0.9758292,0.001913552,0.005803774,0.0005175179,0.00004751563,0.0005988411,0.002324243,0.0001488184,0.01281646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003301112,"threshold_uncertainty_score":0.01104331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02851456333532742,"score_gpt":0.3281677859478988,"score_spread":0.2996532226125714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}