{"id":"W2182832735","doi":"10.1107/s1399004715015497","title":"Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotides","year":2015,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Canada Research Chairs; University Health Network; University of New Brunswick; University of Toronto; York University","funders":"Basic Energy Sciences; National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Brookhaven National Laboratory; Canadian Institutes of Health Research; Canada Research Chairs; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"NAD+ kinase; Nicotinamide mononucleotide; Active site; Biochemistry; Nicotinamide; Chemistry; Nucleotide; Binding site; Stereochemistry; Site-directed mutagenesis; Nicotinamide adenine dinucleotide; Enzyme; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345077,0.0002051093,0.0003019376,0.00007402179,0.0001104644,0.0003037358,0.0003278405,0.0002818599,0.0006841443],"category_scores_gemma":[0.000132898,0.0001480742,0.0002007619,0.000122134,0.0002695449,0.0001717416,0.0001719727,0.0003754941,0.0002678501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004391356,"about_ca_system_score_gemma":0.0001793192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001165631,"about_ca_topic_score_gemma":0.002257798,"domain_scores_codex":[0.9999195,0.00001722063,0.000005315778,0.00002302026,0.00002289291,0.00001195253],"domain_scores_gemma":[0.9999428,0.00001074337,0.00001644524,0.000006542807,0.000007503125,0.00001598354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003171849,0.00003590837,0.002021857,0.00006986298,0.00002188981,0.0001797375,0.00006248732,0.0004326111,0.992658,0.0008583068,0.000104435,0.003237797],"study_design_scores_gemma":[0.00008209493,0.00030612,0.01728106,0.0000147921,0.00006571384,0.001209314,0.0001885908,0.008507289,0.9619333,0.0006332625,0.009736119,0.00004245079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966992,0.0007298925,0.00127806,0.00006619941,0.00001163149,0.000003363493,0.00005765129,0.00003543984,0.00111859],"genre_scores_gemma":[0.997029,0.00033753,0.001558438,0.00003168184,0.000003064491,0.000002374165,0.0001850584,0.000009167605,0.0008436541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165631,"threshold_uncertainty_score":0.003186166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04537812015877215,"score_gpt":0.2836965326038172,"score_spread":0.2383184124450451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}