{"id":"W2183162965","doi":"10.1158/1535-7163.mct-04-0137","title":"Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways","year":2005,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Protein kinase B; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Cytochrome c; Cell biology; Apoptosis; Kinase; Biology; Signal transduction; Phosphorylation; U937 cell; Jurkat cells; Cancer research; Chemistry; Mitochondrion; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304017,0.0004639699,0.0003581714,0.0002351024,0.0001634284,0.0002446619,0.000127784,0.0001881265,0.0007777739],"category_scores_gemma":[0.00008945318,0.0001383909,0.0002601775,0.000279485,0.0001645384,0.0001238624,0.0002080437,0.0003809911,0.0002847331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002747537,"about_ca_system_score_gemma":0.000305206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005951764,"about_ca_topic_score_gemma":0.001502131,"domain_scores_codex":[0.9998011,0.00005094129,0.00002655127,0.00002309038,0.00004914778,0.000049238],"domain_scores_gemma":[0.9999418,0.00000990675,0.00001623105,0.000007536163,0.000006995616,0.00001750131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001378445,0.0001952812,0.0005923263,0.0001314593,0.00002926396,0.0001273496,0.00004670408,0.0002395514,0.9905415,0.0001587313,0.0001799522,0.00637927],"study_design_scores_gemma":[0.0001073095,0.001672658,0.006889154,0.00001187459,0.00005226803,0.00052887,0.00004692395,0.0009916861,0.985551,0.00003635045,0.004105134,0.000006782308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993476,0.003909864,0.0008494558,0.00009495619,0.00003151987,0.00004037793,0.0001983119,0.00008635048,0.001313176],"genre_scores_gemma":[0.9945934,0.002300325,0.001353569,0.00005421876,0.00001394119,0.00007323633,0.0004954108,0.000006186118,0.001109566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007777739,"threshold_uncertainty_score":0.002601922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966831488133376,"score_gpt":0.2596365909492306,"score_spread":0.2399682760678969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}