{"id":"W2183208539","doi":"10.3390/v7122936","title":"Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants","year":2015,"lang":"en","type":"review","venue":"Viruses","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"","keywords":"Potency; Virology; Reoviridae; Computational biology; Biology; Chemistry; Virus; In vitro; Biochemistry; Rotavirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008862923,0.0003964904,0.002350566,0.0003272032,0.00009746961,0.00004576195,0.0001639423,0.0003259934,0.00004919518],"category_scores_gemma":[0.0007231083,0.0002776139,0.0002859848,0.0002248149,0.0002047323,0.000209832,0.0001100544,0.0003529074,0.0000122969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001565917,"about_ca_system_score_gemma":0.0006418229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006821696,"about_ca_topic_score_gemma":0.0001116587,"domain_scores_codex":[0.997314,0.0003194518,0.0008796309,0.0006177553,0.0003598774,0.0005092382],"domain_scores_gemma":[0.9982963,0.00006681611,0.0005456685,0.0004506984,0.0003149018,0.0003256826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006003875,0.000127186,0.00004574231,0.007784499,0.0002908476,0.00008117908,0.00001321267,0.000001490101,0.002228319,0.00003325376,0.001675252,0.9871186],"study_design_scores_gemma":[0.002451858,0.005117204,0.00009094614,0.00463969,0.002717764,0.0006725584,0.00004615247,0.0003634589,0.0001093137,0.00004836473,0.9832818,0.0004608947],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001703728,0.9933221,0.002276198,0.00004913779,0.0001957856,0.001760021,0.0004846722,0.00003746312,0.0001709245],"genre_scores_gemma":[0.0008327381,0.9904474,0.006850096,0.0001347898,0.0009891685,0.0001667169,0.00027501,0.00007302214,0.0002310443],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9866577,"threshold_uncertainty_score":0.9999676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2131958952282462,"score_gpt":0.3987053825217882,"score_spread":0.185509487293542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}