{"id":"W2183672868","doi":"10.1152/ajplung.2000.278.5.l974","title":"Mechanical strain and dexamethasone selectively increase surfactant protein C and tropoelastin gene expression","year":2000,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Tropoelastin; Strain (injury); Dexamethasone; Pulmonary surfactant; Gene; Gene expression; Chemistry; Surfactant protein C; Elastin; Molecular biology; Cell biology; Biology; Biochemistry; Genetics; Endocrinology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002997782,0.000314542,0.0006095986,0.0001065597,0.000127758,0.00001787521,0.0001944012,0.0001589689,0.00006163644],"category_scores_gemma":[0.0001423698,0.000274126,0.0001137697,0.0001502816,0.0008374344,0.00001446797,0.0001802252,0.0003721805,0.000001127766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001345569,"about_ca_system_score_gemma":0.00009529171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004256603,"about_ca_topic_score_gemma":0.000002559564,"domain_scores_codex":[0.9975654,0.0008536395,0.0003674215,0.0006133948,0.0001527038,0.0004474405],"domain_scores_gemma":[0.9990048,0.00007341474,0.0002549704,0.0002568342,0.0001313172,0.0002786467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001476775,0.0001233246,0.00009568342,0.00002926135,0.000182728,0.00002531939,0.00007299781,0.00002631078,0.9836325,0.00005914328,0.00001887713,0.01425706],"study_design_scores_gemma":[0.001552233,0.003669235,0.01246866,0.00003550422,0.0000621901,0.0002000402,0.0002354277,0.0002264362,0.9799677,0.00086833,0.0003732392,0.0003410493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950702,0.003107336,0.00132156,0.0001401133,0.00002047436,0.0002804881,0.00002132412,0.000007227708,0.00003124211],"genre_scores_gemma":[0.995895,0.0008822747,0.002826158,0.0001662428,0.00009771221,0.00001531261,0.00003684968,0.00003959759,0.00004087249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01391601,"threshold_uncertainty_score":0.9999711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004791829291046094,"score_gpt":0.2407743188768764,"score_spread":0.2359824895858303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}