{"id":"W2183967069","doi":"10.4172/2161-0460.s2-0011","title":"Generation of Reactive Oxygen Species (ROS) and Pro-Inflammatory Signaling in Human Brain Cells in Primary Culture.","year":2012,"lang":"en","type":"article","venue":"PubMed","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Surrey Place Centre; Norgen Biotek Corporation (Canada)","funders":"National Institute on Aging","keywords":"Reactive oxygen species; Oxidative stress; Dichlorofluorescein; Neurotoxicity; Cell biology; Phospholipase A2; Neuroinflammation; Chemistry; Biology; Pharmacology; Biochemistry; Inflammation; Immunology; Enzyme; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003166174,0.0003542415,0.0004050815,0.0003735778,0.0004003916,0.0006983539,0.0002847706,0.0002912109,0.004107601],"category_scores_gemma":[0.0002345134,0.0002311569,0.0003486141,0.0004221172,0.0002791518,0.0003505178,0.0002644828,0.001088872,0.002399687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005058856,"about_ca_system_score_gemma":0.0006194208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002321513,"about_ca_topic_score_gemma":0.00652448,"domain_scores_codex":[0.9996562,0.00005159931,0.00004153165,0.00008783133,0.00009916317,0.00006360639],"domain_scores_gemma":[0.9998079,0.00004408005,0.00001924978,0.00003706016,0.0000626082,0.00002910688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001730162,0.0001014976,0.0003759102,0.0001326033,0.00001652679,0.0002127824,0.00008751613,0.0000294892,0.9941422,0.0002974815,0.0008532006,0.003577802],"study_design_scores_gemma":[0.00002968261,0.0003255109,0.007067374,0.0000421951,0.00006144236,0.001037828,0.00018328,0.0003858646,0.9766548,0.0002991266,0.01390351,0.000009345856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.80304,0.06007276,0.06568892,0.002978033,0.002124812,0.0005612872,0.01816457,0.0007163913,0.04665326],"genre_scores_gemma":[0.8969449,0.02687445,0.02511542,0.000577924,0.0002694952,0.0006478478,0.01801369,0.00007799236,0.0314783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004107601,"threshold_uncertainty_score":0.01374125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05442687756630904,"score_gpt":0.239797259499448,"score_spread":0.185370381933139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}