{"id":"W2184596480","doi":"10.1007/s00216-015-9204-2","title":"Initial diagnosis of chronic myelogenous leukemia based on quantification of M-BCR status using droplet digital PCR","year":2015,"lang":"en","type":"article","venue":"Analytical and Bioanalytical Chemistry","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Genome British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"breakpoint cluster region; Chronic myelogenous leukemia; Chromosomal translocation; ABL; Philadelphia chromosome; Biology; Molecular biology; Derivative chromosome; Breakpoint; Fusion gene; Fluorescence in situ hybridization; Chromosome 22; Leukemia; Cancer research; Chromosome; Gene; Tyrosine kinase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585695,0.0002700484,0.0006778908,0.00008998808,0.00003358509,0.00002436946,0.0001031674,0.0002434225,0.0002537798],"category_scores_gemma":[0.0006889249,0.0002170102,0.0002096639,0.0003862908,0.0006347456,0.0000658023,0.00006552902,0.0002454446,0.00001318811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00119059,"about_ca_system_score_gemma":0.001652719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001581691,"about_ca_topic_score_gemma":0.000003053425,"domain_scores_codex":[0.9978575,0.00002124277,0.0006335515,0.0004566838,0.0006147568,0.0004162265],"domain_scores_gemma":[0.9982551,0.0002701616,0.0001711263,0.0004584493,0.0002487156,0.0005964456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01029787,0.01598446,0.7690084,0.009223961,0.004992766,0.001524294,0.0004243272,0.004603303,0.09782983,0.002483692,0.002908059,0.08071905],"study_design_scores_gemma":[0.0104269,0.002219505,0.006977308,0.0007593408,0.002441929,0.0001299254,0.0002544225,0.668237,0.3062775,0.0002835349,0.001320052,0.000672576],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943625,0.0002874588,0.0003680742,0.0002775664,0.0000265396,0.0001798335,0.0001584774,0.00002797397,0.004311543],"genre_scores_gemma":[0.9991649,0.00004627008,0.0002087402,0.00006294923,0.0001508234,0.00000624586,0.0001885387,0.00002332696,0.0001481549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7620311,"threshold_uncertainty_score":0.8849417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0515856623414415,"score_gpt":0.3088899069658027,"score_spread":0.2573042446243612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}