{"id":"W2184596480","doi":"10.1007/s00216-015-9204-2","title":"Initial diagnosis of chronic myelogenous leukemia based on quantification of M-BCR status using droplet digital PCR","year":2015,"lang":"en","type":"article","venue":"Analytical and Bioanalytical Chemistry","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Genome British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"breakpoint cluster region; Chronic myelogenous leukemia; Chromosomal translocation; ABL; Philadelphia chromosome; Biology; Molecular biology; Derivative chromosome; Breakpoint; Fusion gene; Fluorescence in situ hybridization; Chromosome 22; Leukemia; Cancer research; Chromosome; Gene; Tyrosine kinase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007319493,0.0004459271,0.0005572354,0.001130802,0.000278529,0.0005689462,0.000394067,0.0004710866,0.00203712],"category_scores_gemma":[0.001331027,0.0001771568,0.0002242286,0.0005016697,0.00035548,0.000333694,0.0003478331,0.0006757855,0.0007581359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003974913,"about_ca_system_score_gemma":0.0004752503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000841197,"about_ca_topic_score_gemma":0.001405766,"domain_scores_codex":[0.9994129,0.0001045316,0.00005901953,0.0001171625,0.000232377,0.00007413072],"domain_scores_gemma":[0.9995179,0.0001764103,0.00005993073,0.00003693215,0.0001551924,0.0000536174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002703068,0.0005128668,0.3497,0.0008937342,0.0001125357,0.005602267,0.000852816,0.0006887004,0.4570121,0.00227838,0.01018277,0.1694607],"study_design_scores_gemma":[0.0002352613,0.00304521,0.3987572,0.0005304851,0.0003483033,0.03019026,0.001146396,0.0167652,0.4925066,0.004055671,0.05229755,0.0001217857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8964455,0.01054072,0.05304698,0.002052978,0.0006275415,0.002128155,0.004410299,0.001015995,0.02973183],"genre_scores_gemma":[0.9631872,0.001933135,0.027853,0.001147426,0.000175739,0.000343458,0.001734652,0.00004110856,0.003584258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203712,"threshold_uncertainty_score":0.006814778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0515856623414415,"score_gpt":0.3088899069658027,"score_spread":0.2573042446243612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}