{"id":"W2185048627","doi":"10.1182/blood.v124.21.3740.3740","title":"Quantitative Whole Body Autoradiography (QWBA) Analysis Reveals That CPX-351 Shifts the Exposure of Cytarabine (Cyt) and Daunorubicin (Daun) Away from Many Tissues While Providing Prolonged Exposure to Cytotoxic Drug Concentrations in the Bone Marrow Compared to Conventional Free Drug Administration","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"","keywords":"Pharmacology; Chemistry; In vivo; Context (archaeology); Therapeutic index; Toxicity; Drug; Pharmacokinetics; Cytarabine; Daunorubicin; Pharmacodynamics; Medicine; Internal medicine; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003351481,0.0005316923,0.000254353,0.0008027798,0.0003205558,0.0004542373,0.0003854337,0.0004159583,0.006727519],"category_scores_gemma":[0.0001757169,0.000293604,0.0003641961,0.0004909077,0.0005169144,0.0003295615,0.0001786211,0.0009354228,0.001250829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003551035,"about_ca_system_score_gemma":0.0003809973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003062899,"about_ca_topic_score_gemma":0.003947682,"domain_scores_codex":[0.9998347,0.00002012801,0.000009543248,0.00005932167,0.00004420377,0.00003207344],"domain_scores_gemma":[0.9997197,0.00009370731,0.00006384879,0.00003711043,0.0000507478,0.00003487429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403999,0.00001999297,0.0001731608,0.00003936821,0.000007116636,0.0000298867,0.00002506384,0.0000471705,0.9975289,0.0000903245,0.0000578058,0.001840848],"study_design_scores_gemma":[0.00001119933,0.0002228672,0.00875926,0.000008405385,0.00002555493,0.0003217297,0.00006422952,0.0009690756,0.9875941,0.00005374383,0.001960143,0.000009728591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8547074,0.005895307,0.1150247,0.0003609932,0.0002039837,0.0002339963,0.002998067,0.001787283,0.0187882],"genre_scores_gemma":[0.8835812,0.003880065,0.07573072,0.0002727051,0.00004639328,0.000335772,0.002824534,0.0007759213,0.03255272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006727519,"threshold_uncertainty_score":0.02250576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0226830958486664,"score_gpt":0.2858542061588398,"score_spread":0.2631711103101734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}