{"id":"W2185131159","doi":"10.1016/j.biopsych.2015.11.022","title":"Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis","year":2015,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Canada Research Chairs; University College London; Imperial College London; Parkinson's UK; IXICO; Multiple Sclerosis Society; Association France Parkinson; Wellcome Trust; National Institute for Health and Care Research; Teva Pharmaceutical Industries; Medical Research Council; Gedeon Richter; Australian Nuclear Science and Technology Organisation; Biogen; GlaxoSmithKline; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuroinflammation; Hippocampal formation; Neuroscience; Functional connectivity; Multiple sclerosis; Hippocampal sclerosis; Depressive symptoms; Psychology; Medicine; Psychiatry; Cognition; Internal medicine; Inflammation; Temporal lobe","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773963,0.0002447424,0.0002040716,0.0003508444,0.0002401689,0.0002496678,0.00009091278,0.000218795,0.0007323024],"category_scores_gemma":[0.0006022296,0.0001448587,0.0001321147,0.0002275401,0.0002014497,0.0001375094,0.0001941641,0.0002032754,0.00007686728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002322743,"about_ca_system_score_gemma":0.0001223037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001383415,"about_ca_topic_score_gemma":0.002664795,"domain_scores_codex":[0.9999425,0.00001812547,0.000008302403,0.00001172402,0.00001144416,0.0000078487],"domain_scores_gemma":[0.999666,0.00005611056,0.0001754788,0.00001006192,0.00002850069,0.00006382004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007267912,0.0000766892,0.988877,0.00003809076,0.0001139787,0.0003819795,0.0001239322,0.0001510505,0.005063141,0.00001995748,0.00008488178,0.004342516],"study_design_scores_gemma":[0.00001867158,0.0001600026,0.998634,0.000005555285,0.00002306538,0.0007288666,0.00004610022,0.000150983,0.0001620678,0.00003382324,0.00003506618,0.000001760807],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996108,0.0001958429,0.00002350091,0.00002481685,8.631773e-7,0.000002498542,0.00002876815,0.000001611467,0.0001113171],"genre_scores_gemma":[0.9997714,0.00008678934,0.00005530378,0.00001296122,0.000002679962,0.000002723038,0.0000410723,3.018764e-7,0.00002684322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001383415,"threshold_uncertainty_score":0.002750754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1124899121399666,"score_gpt":0.258499272238313,"score_spread":0.1460093600983464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}