{"id":"W2185131159","doi":"10.1016/j.biopsych.2015.11.022","title":"Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis","year":2015,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Canada Research Chairs; University College London; Imperial College London; Parkinson's UK; IXICO; Multiple Sclerosis Society; Association France Parkinson; Wellcome Trust; National Institute for Health and Care Research; Teva Pharmaceutical Industries; Medical Research Council; Gedeon Richter; Australian Nuclear Science and Technology Organisation; Biogen; GlaxoSmithKline; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuroinflammation; Hippocampal formation; Neuroscience; Functional connectivity; Multiple sclerosis; Hippocampal sclerosis; Depressive symptoms; Psychology; Medicine; Psychiatry; Cognition; Internal medicine; Inflammation; Temporal lobe","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001210656,0.0001373029,0.0001411905,0.00006909113,0.00008831573,0.00003851651,0.0001257028,0.0001190615,0.00004029354],"category_scores_gemma":[0.001112772,0.0001050155,0.00004016481,0.0002122612,0.0002116792,0.0001249116,0.00009115076,0.0001596568,0.00004759241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001743533,"about_ca_system_score_gemma":0.00004643391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001031188,"about_ca_topic_score_gemma":0.00004163928,"domain_scores_codex":[0.9987992,0.0001941824,0.0001840726,0.0004493287,0.0001428009,0.0002304135],"domain_scores_gemma":[0.9993446,0.0003025503,0.00006516599,0.0001306061,0.00001982818,0.0001372019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002386061,0.0002602016,0.9437196,0.00000649681,0.000003305223,0.000003825509,0.0000663488,0.0001225113,0.04452985,0.006057807,0.001792014,0.003199457],"study_design_scores_gemma":[0.001996084,0.0001864467,0.9821351,0.00001283531,0.000001603291,0.00001607811,0.00006760653,0.0005118901,0.001562218,0.01302329,0.00030835,0.0001785173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968633,0.0002280502,0.0001464272,0.001007514,0.0006997132,0.0002008782,0.00001046848,0.00009684893,0.0007467674],"genre_scores_gemma":[0.9986682,0.00002819863,0.00009692181,0.001019276,0.0001319789,0.00002368679,0.000004462291,0.000007445894,0.00001980925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04296763,"threshold_uncertainty_score":0.4282409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1124899121399666,"score_gpt":0.258499272238313,"score_spread":0.1460093600983464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}