{"id":"W2185432117","doi":"10.2337/db15-0950","title":"Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Novo Nordisk Fonden","keywords":"Metformin; Insulin resistance; Medicine; Waist; Type 2 diabetes; Glycemic; Diabetes mellitus; Internal medicine; Population; Genome-wide association study; Insulin; Body mass index; Endocrinology; Single-nucleotide polymorphism; Genetics; Genotype; Biology; Gene; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00131033,0.0001337158,0.0003194844,0.00005575773,0.00003099643,0.00001144161,0.0001299199,0.000176721,0.000001700029],"category_scores_gemma":[0.001526556,0.0001094397,0.00005752556,0.0002441107,0.0001477517,0.000009308249,0.000171489,0.00008884644,8.20255e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001483627,"about_ca_system_score_gemma":0.0001254836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000075149,"about_ca_topic_score_gemma":0.0002849961,"domain_scores_codex":[0.9982805,0.0005266218,0.0004525197,0.0002699265,0.0001421273,0.0003282726],"domain_scores_gemma":[0.9990278,0.00007523911,0.0003400756,0.0003085955,0.0001705002,0.0000777926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000286775,0.0001799219,0.8802539,0.00005184374,0.00006862828,5.463184e-7,0.0002701597,0.0005465789,0.1107098,0.00001113978,0.00009873494,0.007780084],"study_design_scores_gemma":[0.0009733701,0.0002775215,0.9115657,0.00006998225,0.00004783889,3.647732e-7,0.0002166825,0.001740695,0.08362152,0.001137442,0.0001968453,0.000152041],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973263,0.001977901,0.00002397331,0.00008894873,0.0000746361,0.0003783143,0.00003372544,0.000005721987,0.00009048051],"genre_scores_gemma":[0.9974089,0.0001261826,0.002219197,0.00002949899,0.00004389789,0.00005714903,0.00002768118,0.00001268039,0.00007477662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03131183,"threshold_uncertainty_score":0.4462821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01968334375829875,"score_gpt":0.2722827951420608,"score_spread":0.2525994513837621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}