{"id":"W2185432117","doi":"10.2337/db15-0950","title":"Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Novo Nordisk Fonden","keywords":"Metformin; Insulin resistance; Medicine; Waist; Type 2 diabetes; Glycemic; Diabetes mellitus; Internal medicine; Population; Genome-wide association study; Insulin; Body mass index; Endocrinology; Single-nucleotide polymorphism; Genetics; Genotype; Biology; Gene; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001101324,0.0003699331,0.000496183,0.0002387224,0.0002086263,0.0004861921,0.0003010474,0.0004626267,0.001606965],"category_scores_gemma":[0.002909256,0.0002949577,0.0008771284,0.0002712666,0.0001664065,0.0002370899,0.0004516683,0.0006905385,0.0001463276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000165319,"about_ca_system_score_gemma":0.0003395137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001515339,"about_ca_topic_score_gemma":0.002545725,"domain_scores_codex":[0.999616,0.0001783072,0.00003057158,0.00006497544,0.00006105059,0.00004901111],"domain_scores_gemma":[0.9993213,0.0001736001,0.000222929,0.00009570536,0.00003594967,0.0001505108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09669223,0.01629548,0.6981027,0.0007135873,0.008548867,0.0005375814,0.0007429959,0.002390899,0.02663447,0.0004043401,0.001890613,0.1470463],"study_design_scores_gemma":[0.002503571,0.01398527,0.9765781,0.0000514536,0.001925094,0.0001421945,0.0001055701,0.001518677,0.001904112,0.000436089,0.0008299171,0.0000198689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987597,0.0003376868,0.0001570519,0.0001196116,0.00001698517,0.00002243512,0.0001259179,0.0000267344,0.0004337168],"genre_scores_gemma":[0.9987804,0.0001766634,0.0003847051,0.00009829336,0.00001466184,0.00002882237,0.0001441076,0.000005060449,0.0003673599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606965,"threshold_uncertainty_score":0.005824447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01968334375829875,"score_gpt":0.2722827951420608,"score_spread":0.2525994513837621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}