{"id":"W2185595601","doi":"10.7448/ias.18.1.20824","title":"Implications for the future of the HIV epidemic if drug resistance against dolutegravir cannot occur in first‐line therapy","year":2015,"lang":"en","type":"article","venue":"Journal of the International AIDS Society","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Dolutegravir; Medicine; Emtricitabine; Drug resistance; Resistance mutation; Lamivudine; Integrase inhibitor; Virology; Regimen; Drug; Clinical trial; Pharmacology; Protease inhibitor (pharmacology); Reverse transcriptase; Internal medicine; Human immunodeficiency virus (HIV); Antiretroviral therapy; Viral load; Virus; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005719224,0.0006269523,0.001070084,0.0005856429,0.001994544,0.004312355,0.001460402,0.008986142,0.02084929],"category_scores_gemma":[0.01953242,0.0002019258,0.000604827,0.0005759378,0.005769473,0.007581082,0.001919885,0.009079738,0.003649174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002976419,"about_ca_system_score_gemma":0.004405844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002649562,"about_ca_topic_score_gemma":0.003994104,"domain_scores_codex":[0.9972561,0.001084647,0.0001806562,0.0004608721,0.0006472392,0.0003705559],"domain_scores_gemma":[0.9882404,0.005403028,0.001245441,0.0004625377,0.002028825,0.002619743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000741907,0.0003077287,0.006542612,0.001399539,0.0001224898,0.004368604,0.0009502434,0.001412083,0.001455249,0.1645417,0.5238333,0.2943246],"study_design_scores_gemma":[0.00009089318,0.0002802287,0.004266933,0.002567271,0.00007810787,0.003420306,0.00368765,0.0007737342,0.0005709131,0.2921929,0.6919553,0.0001158659],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.003150419,0.06482436,0.001178644,0.9023933,0.009466751,0.000008575894,0.0002033276,0.00007652408,0.01869805],"genre_scores_gemma":[0.2037197,0.2088128,0.006024871,0.4987148,0.06381013,0.00009096281,0.0003867599,0.0001588647,0.01828106],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02084929,"threshold_uncertainty_score":0.06974781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02946233438640973,"score_gpt":0.3040986346032424,"score_spread":0.2746363002168327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}