{"id":"W2185841293","doi":"10.1186/s13024-015-0061-4","title":"Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample","year":2015,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia; University of British Columbia Hospital","funders":"Canadian Institutes of Health Research; National Institute on Aging; Michael Smith Health Research BC","keywords":"Dementia; Cognition; Cognitive decline; GABAergic; Neuroscience; Glutamatergic; Psychology; Medicine; Disease; Biology; Internal medicine; Glutamate receptor; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005097631,0.0001210912,0.0002825116,0.0001597777,0.00003272063,0.000007543506,0.00004532955,0.00005147586,0.000006857867],"category_scores_gemma":[0.0008071385,0.0001059042,0.0000310622,0.0003059444,0.00008291797,0.00006813594,0.00006000649,0.0001776051,6.116879e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003668162,"about_ca_system_score_gemma":0.0001791543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005676788,"about_ca_topic_score_gemma":0.00247519,"domain_scores_codex":[0.9983372,0.0007320885,0.0002760775,0.0001668916,0.0003293834,0.000158375],"domain_scores_gemma":[0.9990602,0.0001855074,0.0001591775,0.0001905107,0.000265736,0.0001388604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001120956,0.001519403,0.9904054,0.00005095161,0.0009238981,0.0007107266,0.0006681629,0.00006043532,0.004253873,0.000005816893,0.000003237345,0.0002771708],"study_design_scores_gemma":[0.007912106,0.001114357,0.9041422,0.000221387,0.0007225115,0.00002674237,0.0001154389,0.00388877,0.0816471,0.0001170449,2.513689e-7,0.00009210955],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976815,0.001020938,0.0005615659,0.00004357046,0.00000483644,0.0004977412,0.000155971,0.000006321096,0.00002757736],"genre_scores_gemma":[0.9991418,0.00008261961,0.0002257313,0.0001102966,0.000004080572,0.00002536555,0.000393889,0.00001538821,8.474177e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08626319,"threshold_uncertainty_score":0.8581643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02894215655888746,"score_gpt":0.3018973110701008,"score_spread":0.2729551545112134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}