{"id":"W2185903804","doi":"","title":"Toward a generic approach for stress testing of drug substances and drug products","year":2005,"lang":"en","type":"article","venue":"VU Research Portal","topic":"Pesticide Residue Analysis and Safety","field":"Agricultural and Biological Sciences","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"AkzoNobel (Canada)","funders":"","keywords":"Drug; Profiling (computer programming); Stress testing (software); Drug development; Reliability engineering; Computer science; Biochemical engineering; Pharmacology; Engineering; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001189931,0.00009338935,0.0001980242,0.00002906945,0.0001965698,0.00004816028,0.000222011,0.00003257821,0.0000453258],"category_scores_gemma":[0.0004596894,0.00003598579,0.00005154068,0.0006467244,0.000154791,0.000117526,0.00007713506,0.0001207891,0.000001286151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008164197,"about_ca_system_score_gemma":0.00002842233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000476405,"about_ca_topic_score_gemma":0.0007431461,"domain_scores_codex":[0.9985057,0.00009937003,0.0002352894,0.00034307,0.0004308447,0.0003857923],"domain_scores_gemma":[0.998992,0.0004244215,0.0000772372,0.00006501096,0.000334804,0.0001065269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001445748,0.0009362735,0.2255526,0.0004069681,0.0001398279,0.00002553214,0.001314887,0.0004485962,0.3054405,0.002066006,0.0110008,0.4525234],"study_design_scores_gemma":[0.000948287,0.0007851731,0.7890092,0.0001901524,0.0001067525,0.00004289594,0.01071051,0.01850246,0.1516887,0.001398402,0.0255695,0.001047942],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942456,0.001962224,0.000007692947,0.001066316,0.000008378976,0.000284327,0.0000609347,0.00001693483,0.002347525],"genre_scores_gemma":[0.9958488,0.0001510394,0.003042635,0.00001247283,0.0003544055,0.00003966201,0.00006333275,0.000001126331,0.0004865442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5634566,"threshold_uncertainty_score":0.1511876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129224076889809,"score_gpt":0.3184487164285627,"score_spread":0.1892246395387536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}