{"id":"W2185903804","doi":"","title":"Toward a generic approach for stress testing of drug substances and drug products","year":2005,"lang":"en","type":"article","venue":"VU Research Portal","topic":"Pesticide Residue Analysis and Safety","field":"Agricultural and Biological Sciences","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"AkzoNobel (Canada)","funders":"","keywords":"Drug; Profiling (computer programming); Stress testing (software); Drug development; Reliability engineering; Computer science; Biochemical engineering; Pharmacology; Engineering; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006448827,0.001754491,0.00152446,0.003238573,0.0005599588,0.001347392,0.002068369,0.002227379,0.002165444],"category_scores_gemma":[0.004436532,0.0005936236,0.00145634,0.001154487,0.001187062,0.001828641,0.001940852,0.00194722,0.001902159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006975759,"about_ca_system_score_gemma":0.001164758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005146281,"about_ca_topic_score_gemma":0.0008855142,"domain_scores_codex":[0.9932685,0.002297386,0.0004813491,0.001014186,0.002723274,0.0002153358],"domain_scores_gemma":[0.9971116,0.0004297923,0.0004536826,0.0008752532,0.001002774,0.0001269735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004620479,0.0007495401,0.0050152,0.0007646107,0.0001660613,0.0002718297,0.0001518544,0.005928099,0.7190987,0.006961904,0.002748983,0.2576812],"study_design_scores_gemma":[0.00019466,0.004583207,0.009374541,0.0001567739,0.000319343,0.003195773,0.0001554437,0.06347509,0.8815912,0.008412321,0.02835079,0.0001909268],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01939112,0.0009121136,0.9718975,0.0004420092,0.00008443065,0.0008432253,0.00043402,0.003286217,0.002709243],"genre_scores_gemma":[0.1081156,0.00145823,0.8854313,0.0007708663,0.0001478164,0.0007163369,0.0008805621,0.0002311575,0.00224825],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.006448827,"threshold_uncertainty_score":0.034105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129224076889809,"score_gpt":0.3184487164285627,"score_spread":0.1892246395387536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}