{"id":"W2185946585","doi":"10.1016/j.yjmcc.2015.11.026","title":"Engineered Cx40 variants increased docking and function of heterotypic Cx40/Cx43 gap junction channels","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Ministry of Education, Culture, Sports, Science and Technology; Heart and Stroke Foundation of Canada","keywords":"Gap junction; Connexin; Docking (animal); Homology modeling; Myocyte; Cell biology; Chemistry; Biophysics; Biology; Intracellular; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003642518,0.0005624753,0.0005158792,0.0002394395,0.0002967635,0.0006561379,0.0003497701,0.0007680586,0.003722487],"category_scores_gemma":[0.0003666226,0.0002593733,0.0003847204,0.0002098267,0.0004422787,0.0005135359,0.0004041872,0.001131929,0.0004593186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005131253,"about_ca_system_score_gemma":0.0002487672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008934354,"about_ca_topic_score_gemma":0.001015048,"domain_scores_codex":[0.9995265,0.00005714099,0.00006739825,0.0001001526,0.00009570183,0.000153143],"domain_scores_gemma":[0.9996464,0.00007750745,0.00006950984,0.00005005107,0.00004107543,0.0001154757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000174674,0.00008201723,0.0000550022,0.00002060147,0.00001106919,0.00006761625,0.00002161471,0.0001261713,0.9987683,0.0002474926,0.00003592717,0.0003895172],"study_design_scores_gemma":[0.00003453632,0.0002653668,0.001155238,0.000003637561,0.00002927012,0.0002443818,0.00003464749,0.001815033,0.9954247,0.00005978836,0.0009239961,0.000009399836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978941,0.0002013158,0.001211726,0.00004205297,0.00005567092,0.00001498618,0.0001105679,0.00004352264,0.0004259815],"genre_scores_gemma":[0.9975429,0.0001256353,0.0008925301,0.00003776018,0.00001280865,0.0000120235,0.0001220298,0.00005211407,0.001202265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003722487,"threshold_uncertainty_score":0.01245296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395051881344729,"score_gpt":0.2107384120000774,"score_spread":0.1967878931866301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}