{"id":"W2186092389","doi":"10.1124/mol.105.015891","title":"Inactivation of the Pure Antiestrogen Fulvestrant and Other Synthetic Estrogen Molecules by UDP-Glucuronosyltransferase 1A Enzymes Expressed in Breast Tissue","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"","keywords":"Glucuronidation; Fulvestrant; Enzyme; Chemistry; Glucuronosyltransferase; Antiestrogen; Biochemistry; Estrogen; Estrogen receptor; Microsome; Biology; Cancer; Endocrinology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004735205,0.0004221521,0.0004893417,0.0001816945,0.0001475529,0.00001891472,0.0005372267,0.0003551173,0.0006365058],"category_scores_gemma":[0.00001977395,0.0003722188,0.0001345077,0.0003407213,0.0005138551,0.0001107143,0.0001411743,0.0007323148,0.00001502024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005689193,"about_ca_system_score_gemma":0.0001223624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004933963,"about_ca_topic_score_gemma":0.000006978504,"domain_scores_codex":[0.9968547,0.00107852,0.0006213211,0.0005522486,0.0002411966,0.0006519802],"domain_scores_gemma":[0.9990243,0.0001649146,0.0002132953,0.0002764364,0.00007793545,0.0002431216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004311756,0.0005884452,0.001815211,0.0000552731,0.0002140702,0.00003354729,0.0004637697,0.001570832,0.9808921,0.001075661,0.001066839,0.01179307],"study_design_scores_gemma":[0.00296046,0.00006320482,0.0005520721,0.00001515667,0.000307158,0.00007916358,0.00004664183,0.002118562,0.8832696,0.000183814,0.1100956,0.0003085819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845935,0.008694531,0.0005151666,0.003688817,0.0004899163,0.0008693904,0.0005559431,0.00004345938,0.0005493449],"genre_scores_gemma":[0.994463,0.0007021589,0.0001861277,0.004229853,0.000142676,0.0001296438,0.00001904926,0.00006361154,0.00006390343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1090288,"threshold_uncertainty_score":0.999873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167709174274309,"score_gpt":0.3447819343085265,"score_spread":0.3231048425657835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}