{"id":"W2186297315","doi":"10.1371/journal.ppat.1005290","title":"Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Uniformed Services University of the Health Sciences","keywords":"Neisseria gonorrhoeae; Alternative complement pathway; Sialyltransferase; Sialic acid; Classical complement pathway; Microbiology; Neuraminic acid; Chemistry; Complement system; Bacteria; Biochemistry; Biology; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112685,0.0002884431,0.0001631722,0.00008883086,0.00007423761,0.000229417,0.0001911737,0.0002599772,0.0005123089],"category_scores_gemma":[0.0001128696,0.0001049606,0.0001493007,0.00007969307,0.0002107337,0.0002337597,0.0002027622,0.0004246046,0.0001863251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339776,"about_ca_system_score_gemma":0.0002275392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006183506,"about_ca_topic_score_gemma":0.001129992,"domain_scores_codex":[0.9999429,0.00001009028,0.000004204952,0.000009156911,0.00001729956,0.00001638411],"domain_scores_gemma":[0.9999651,0.000004822718,0.000009296235,0.000004276637,0.000005921424,0.00001059593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006044289,0.0000341346,0.00009691788,0.00005325456,0.000004550703,0.00005094716,0.00001346887,0.0003861509,0.9951882,0.0003266973,0.0000336195,0.003751589],"study_design_scores_gemma":[0.0000333233,0.0009043164,0.0004465442,0.00000860066,0.00001034612,0.0001891628,0.00001573065,0.001370857,0.9925114,0.00009727417,0.004406494,0.000006033526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849879,0.002712515,0.008213208,0.0002438487,0.00003621978,0.0001842802,0.0001430017,0.00008263675,0.003396491],"genre_scores_gemma":[0.9899912,0.001797921,0.00653387,0.0001123826,0.000008486237,0.00005894005,0.0001300654,0.00001130359,0.001355894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006183506,"threshold_uncertainty_score":0.002423227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.108969436869956,"score_gpt":0.2845472621303984,"score_spread":0.1755778252604424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}