{"id":"W2186374947","doi":"10.1016/j.bbadis.2015.07.015","title":"Cardiomyocyte–fibroblast interaction contributes to diabetic cardiomyopathy in mice: Role of HMGB1/TLR4/IL-33 axis","year":2015,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Natural Science Foundation of China; King Abdulaziz City for Science and Technology; Interthyr Research Foundation","keywords":"Fibroblast; HMGB1; Diabetic cardiomyopathy; Myocyte; Cardiac fibrosis; Endocrinology; Internal medicine; Myocardial fibrosis; Myofibroblast; Western blot; Fibrosis; TLR4; Medicine; Biology; Chemistry; Cell culture; Receptor; Cardiomyopathy; Heart failure; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003283039,0.0005041786,0.001013996,0.0005319907,0.00007131232,0.00003210625,0.0005720379,0.0002752849,0.00001154326],"category_scores_gemma":[0.0004923384,0.0005130364,0.0005648879,0.00074014,0.0003330275,0.0001986687,0.0003456116,0.0003189114,0.0001168676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001466147,"about_ca_system_score_gemma":0.0004584652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002932204,"about_ca_topic_score_gemma":0.00001421156,"domain_scores_codex":[0.997032,0.000606875,0.0007662483,0.0007496628,0.0002031815,0.0006420709],"domain_scores_gemma":[0.997996,0.0001251376,0.0003621146,0.0008643229,0.0004033146,0.000249059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001691247,0.0006935973,0.000232565,0.0001540212,0.0005249872,0.00001412556,0.0006140734,0.00006664224,0.9942937,0.0003013137,0.0009916399,0.0004220722],"study_design_scores_gemma":[0.002188668,0.000509121,0.01044818,0.0003150198,0.0003523816,0.000003751078,0.0006401797,0.00001613511,0.9819514,0.0003810409,0.002718682,0.0004754025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899683,0.0009648903,0.0001083515,0.0004573292,0.0003967604,0.0007276704,0.006726708,0.00006710848,0.000582904],"genre_scores_gemma":[0.9987068,0.0000657327,0.0001081248,0.0002359843,0.00005018042,0.0001014901,0.0006321772,0.00006300308,0.00003657893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01234228,"threshold_uncertainty_score":0.9997321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008913048684496348,"score_gpt":0.2331437850850213,"score_spread":0.224230736400525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}