{"id":"W2186374947","doi":"10.1016/j.bbadis.2015.07.015","title":"Cardiomyocyte–fibroblast interaction contributes to diabetic cardiomyopathy in mice: Role of HMGB1/TLR4/IL-33 axis","year":2015,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Natural Science Foundation of China; King Abdulaziz City for Science and Technology; Interthyr Research Foundation","keywords":"Fibroblast; HMGB1; Diabetic cardiomyopathy; Myocyte; Cardiac fibrosis; Endocrinology; Internal medicine; Myocardial fibrosis; Myofibroblast; Western blot; Fibrosis; TLR4; Medicine; Biology; Chemistry; Cell culture; Receptor; Cardiomyopathy; Heart failure; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003360637,0.0006244974,0.0003096906,0.0007376953,0.0003382818,0.0004180825,0.0002124303,0.000553393,0.00197825],"category_scores_gemma":[0.0001473718,0.0004048094,0.0004130705,0.0001613352,0.00047503,0.0003130758,0.0004729286,0.001489356,0.000338064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002846023,"about_ca_system_score_gemma":0.0002860528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003788914,"about_ca_topic_score_gemma":0.0008731026,"domain_scores_codex":[0.9996674,0.00007279804,0.00002794161,0.00006639339,0.00008087944,0.00008459068],"domain_scores_gemma":[0.9997019,0.00001886106,0.0001027903,0.00002017365,0.0000160714,0.0001400658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007744062,0.0000765904,0.001387581,0.00004748903,0.0000151971,0.0002907436,0.00003237828,0.00005636026,0.9956242,0.0002745985,0.00008612825,0.00133417],"study_design_scores_gemma":[0.0003043062,0.001082437,0.08079337,0.0000804097,0.0003037392,0.002407057,0.0005843616,0.003969227,0.9045917,0.001035042,0.004812056,0.00003634002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923121,0.001840764,0.003381574,0.0004043749,0.00007070326,0.00002720322,0.0003775962,0.00009856927,0.001486955],"genre_scores_gemma":[0.9950138,0.0007227272,0.001450278,0.0001387741,0.00002712708,0.00004737996,0.0002014224,0.00002097594,0.002377466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00197825,"threshold_uncertainty_score":0.006617904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008913048684496348,"score_gpt":0.2331437850850213,"score_spread":0.224230736400525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}