{"id":"W2186803051","doi":"10.1371/journal.pgen.1005694","title":"Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; University of Oxford; National Institute of Mental Health; Medical Research Council; Novo Nordisk; Canadian Institutes of Health Research; National Institute for Health and Care Research; Alberta Diabetes Foundation; University of Alberta; Wellcome Trust","keywords":"Biology; Expression quantitative trait loci; Genome-wide association study; Glucose homeostasis; Genetics; Locus (genetics); Regulation of gene expression; Genetic association; Quantitative trait locus; Gene; Single-nucleotide polymorphism; Insulin; Endocrinology; Insulin resistance; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003716473,0.0002585408,0.0004301847,0.00004409177,0.0001341401,0.00002924332,0.000359722,0.0004813169,0.000006756199],"category_scores_gemma":[0.001646662,0.0002333799,0.00006109031,0.00006798906,0.00005252433,0.000006765233,0.0002460815,0.0001278422,0.000006960413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006442922,"about_ca_system_score_gemma":0.00006424938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000942763,"about_ca_topic_score_gemma":0.00006088265,"domain_scores_codex":[0.9981998,0.0002133756,0.0003975819,0.0006579985,0.0001654558,0.0003657605],"domain_scores_gemma":[0.9982604,0.000498174,0.0002177605,0.0005535696,0.0002781907,0.0001918748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007206872,0.00006200248,0.05555668,0.00001464314,0.0004275758,1.869037e-7,0.0005765443,0.000222528,0.9269937,3.590106e-7,0.0156772,0.0003964829],"study_design_scores_gemma":[0.002451503,0.001646953,0.07518063,0.00008601011,0.0004443173,1.721079e-7,0.0008067128,0.0009310993,0.8975434,0.002008798,0.01817199,0.0007284454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863634,0.01085393,0.0003627056,0.0004477512,0.0002270142,0.0005256172,0.001178204,0.00002165229,0.00001978495],"genre_scores_gemma":[0.9921275,0.000439717,0.002913332,0.000892444,0.0005738811,0.00006277137,0.002865488,0.00004288389,0.00008203049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02945036,"threshold_uncertainty_score":0.9516954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09119030685196204,"score_gpt":0.3143462693025931,"score_spread":0.223155962450631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}