{"id":"W2187281613","doi":"10.1158/1055-9965.583.13.4","title":"Polymorphisms XRCC1-R399Q and XRCC3-T241M and the Risk of Breast Cancer at the Ontario Site of the Breast Cancer Family Registry","year":2004,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"XRCC1; Breast cancer; XRCC3; Odds ratio; Genotype; Internal medicine; Confidence interval; Family history; Medicine; Oncology; Cancer; Heterozygote advantage; Breast disease; Single-nucleotide polymorphism; Gastroenterology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004224195,0.0001957072,0.0002213579,0.0004257886,0.0004947411,0.0004108337,0.0004236513,0.0002923356,0.001142511],"category_scores_gemma":[0.002612973,0.0002222118,0.0003109803,0.0007772812,0.0003639862,0.0001445146,0.0002501732,0.0002454472,0.0001297277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001969222,"about_ca_system_score_gemma":0.001629075,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.5906855,"about_ca_topic_score_gemma":0.6291252,"domain_scores_codex":[0.9995584,0.00009714936,0.00002308565,0.0001043309,0.0001300821,0.00008693493],"domain_scores_gemma":[0.9982371,0.0002603432,0.0009695459,0.000106971,0.0001710573,0.0002548963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001047368,0.000005631875,0.998771,0.000005489118,0.00003486343,0.00004884947,0.00006653996,0.00002704649,0.0002787651,0.00001189361,0.00007400867,0.0005710478],"study_design_scores_gemma":[0.000005622968,0.0000117128,0.9996538,0.000002324685,0.00001788568,0.00009008339,0.00003060949,0.00006243609,0.00002796963,0.000006058567,0.00009022088,0.000001304121],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987128,0.0003658895,0.00004251744,0.00005991952,0.00000199205,0.000004929327,0.0004476666,0.000003240309,0.0003610576],"genre_scores_gemma":[0.9992036,0.0001593017,0.00005601021,0.00001112571,0.000003756571,0.000003505018,0.0003136893,0.000001684099,0.0002472277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4093145,"threshold_uncertainty_score":0.82345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103276232168402,"score_gpt":0.2617007743595748,"score_spread":0.2506680120378907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}