{"id":"W2187341651","doi":"10.1038/nchembio.1890","title":"Minimum Information about a Biosynthetic Gene cluster","year":2015,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":908,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; McMaster University; Memorial University of Newfoundland","funders":"Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie – Hans-Knöll-Institut; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences; Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional; Biotechnology and Biological Sciences Research Council; Tufts University School of Medicine; Institute for Bioengineering and Biosciences; State Key Laboratory of Microbial Metabolism; Novo Nordisk Fonden; Institute of Oceanology, Chinese Academy of Sciences; Korea Advanced Institute of Science and Technology; Institut National de la Recherche Agronomique; Novartis Institutes for BioMedical Research; Veterinärmedizinische Universität Wien; Universidad de Oviedo; Advanced Scientific Computing Research; Universidade de Lisboa; Memorial University of Newfoundland; Turun Yliopisto; Shanghai Jiao Tong University; Centre National de la Recherche Scientifique; University of Tokyo; Universität des Saarlandes; Universiteit Gent; Slovenská Akadémia Vied; Deutsches Zentrum für Infektionsforschung; Akademie Věd České Republiky; University of Pittsburgh; National University of Ireland; University of New South Wales; KU Leuven; Danmarks Tekniske Universitet; Koninklijke Nederlandse Akademie van Wetenschappen; Instituto Politécnico Nacional; Chalmers Tekniska Högskola; National Cancer Institute; Albert-Ludwigs-Universität Freiburg; University of California, San Diego; Université Paris Diderot; Myongji University; University of California, Los Angeles; Curtin University of Technology; Rijksuniversiteit Groningen; University College Cork; University College Dublin; Directorate for Biological Sciences; King Abdulaziz University; Division of Chemistry; Technische Universität Berlin; University of Bristol; University of Leeds; Nederlands Instituut voor Ecologie; California State University, Chico; University of Illinois at Urbana-Champaign; William Paterson University of New Jersey; Gordon and Betty Moore Foundation; McMaster University; Novo Nordisk; Oregon State University; National Science Foundation; University of Minnesota; Université de Lorraine; University of North Texas; University of Arkansas for Medical Sciences; Skaggs School of Pharmacy and Pharmaceutical Sciences; Helsingin Yliopisto; Massey University; Hokkaido University; University of Connecticut; Joint Genome Institute; Instituto Superior Técnico; Chinese Academy of Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Harvard University; Friedrich-Schiller-Universität Jena; Energy Biosciences Institute; California Institute for Quantitative Biosciences; Engineering and Physical Sciences Research Council; European Commission; University of Alberta; South China Sea Institute of Oceanology, Chinese Academy of Sciences; U.S. Department of Energy; University of Wisconsin-Madison; Natural Environment Research Council; Eberhard Karls Universität Tübingen; Princeton University; Leibniz-Gemeinschaft; Roosevelt University","keywords":"Gene cluster; Gene; Computational biology; Cluster (spacecraft); Biology; Metabolic pathway; Biological pathway; Exploit; Genetics; Gene expression; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0004765768,0.0007799125,0.001458483,0.001607342,0.0006966179,0.001204376,0.0009304517,0.001191811,0.006716656],"category_scores_gemma":[0.004484002,0.0004788237,0.0009640014,0.001866143,0.0004288422,0.001946847,0.000829373,0.001307415,0.001791271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000504026,"about_ca_system_score_gemma":0.001159082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000980414,"about_ca_topic_score_gemma":0.001066849,"domain_scores_codex":[0.9992824,0.0001029502,0.00008309542,0.0001997112,0.000230242,0.0001015358],"domain_scores_gemma":[0.9972485,0.001406075,0.0001719723,0.0006091875,0.0004442487,0.0001200159],"domain_codex":null,"domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01007629,0.0006210068,0.01368463,0.004831874,0.0003960445,0.001555031,0.0008871493,0.09296635,0.36971,0.1349663,0.03707917,0.3332263],"study_design_scores_gemma":[0.0006144164,0.0009223601,0.01607499,0.0005940624,0.0004793376,0.001128252,0.0003541023,0.1765889,0.1508437,0.6053046,0.04688102,0.0002142422],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4029071,0.001520098,0.4402964,0.002206653,0.0002731075,0.0002636867,0.1262661,0.005748749,0.02051814],"genre_scores_gemma":[0.7187978,0.0006641474,0.2101323,0.0002928975,0.0001431272,0.000418039,0.06646065,0.0006420752,0.002449014],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.9995234,"threshold_uncertainty_score":0.02246952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104907457798953,"score_gpt":0.2614603195163012,"score_spread":0.2504112449383117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}