{"id":"W2187919348","doi":"10.1016/j.mrfmmm.2015.09.005","title":"Gene-specific DNA methylation of DNMT3B and MTHFR and colorectal adenoma risk","year":2015,"lang":"en","type":"article","venue":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Methylenetetrahydrofolate reductase; Methylation; CpG site; Colorectal adenoma; Colorectal cancer; Epigenetics; Biology; Methyltransferase; DNMT3B; Odds ratio; Genetics; Cancer research; Medicine; Oncology; Internal medicine; Genotype; Gene; Cancer; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003598102,0.0001205951,0.0001566879,0.0003516471,0.00008446803,0.0001286244,0.0001895254,0.0002474888,0.001013707],"category_scores_gemma":[0.00102969,0.000119133,0.0001588174,0.0003631304,0.0001840367,0.0001184058,0.000126192,0.0002919295,0.00009524602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000324788,"about_ca_system_score_gemma":0.0003164472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005981371,"about_ca_topic_score_gemma":0.004584887,"domain_scores_codex":[0.9998791,0.00004342665,0.000007809715,0.0000223098,0.00003326682,0.00001398234],"domain_scores_gemma":[0.9997911,0.00005582289,0.00008192282,0.00001551651,0.0000231726,0.00003256549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00451698,0.0001369172,0.6763766,0.0004511893,0.0006762946,0.0005550663,0.0002305344,0.001282772,0.2277243,0.003871788,0.0007643127,0.08341326],"study_design_scores_gemma":[0.00004555957,0.0004809744,0.9592017,0.00004063467,0.0003693908,0.00197445,0.00008357516,0.001234888,0.0314333,0.001643111,0.003475615,0.00001679246],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746078,0.02194145,0.001208589,0.0006463381,0.00002324714,0.00000878518,0.0003196304,0.00001877974,0.001225317],"genre_scores_gemma":[0.9965257,0.002606602,0.0003316785,0.00002281153,0.00001233049,0.000002308434,0.00008299122,0.000001397853,0.0004141267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005981371,"threshold_uncertainty_score":0.01189315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736062451744292,"score_gpt":0.3064405561143346,"score_spread":0.2690799315968917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}