{"id":"W2188010897","doi":"10.1002/chir.22054","title":"Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes","year":2012,"lang":"en","type":"article","venue":"Chirality","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Université de Montréal","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Chemistry; Internal medicine; Endocrinology; Metabolism; Metabolite; Hepatocyte; Enantiomer; Cytochrome P450; Biochemistry; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002162958,0.0004112483,0.000689532,0.0001019855,0.0001974881,0.00001325131,0.0003430645,0.0002995083,0.001165331],"category_scores_gemma":[0.0001671655,0.0003327157,0.000239248,0.0002723629,0.000215337,0.0001629037,0.0001333366,0.0007851501,0.0001777129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004526462,"about_ca_system_score_gemma":0.00003778202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004929835,"about_ca_topic_score_gemma":0.000002188857,"domain_scores_codex":[0.9964675,0.001633111,0.0004708963,0.0003589004,0.0002778998,0.0007916357],"domain_scores_gemma":[0.9983684,0.0004708416,0.0002603966,0.0003553753,0.000088294,0.0004566484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003134722,0.002205545,0.1406586,0.0003911026,0.000934464,0.000009300422,0.001218471,0.0000503647,0.6214631,0.003082765,0.008752917,0.2180987],"study_design_scores_gemma":[0.002591619,0.0002785982,0.02081215,0.00000814965,0.0003345914,0.000004926487,0.000006228659,0.0001008114,0.8504378,0.0001306416,0.1250138,0.0002806782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842563,0.006809373,0.00003157154,0.0002136123,0.002314635,0.0009113361,0.0005342844,0.00008509716,0.004843831],"genre_scores_gemma":[0.9970257,0.000399201,0.00004003199,0.001107679,0.0006856967,0.0001044364,0.00003360206,0.00003878008,0.0005649091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2289748,"threshold_uncertainty_score":0.9999125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.057126775801462,"score_gpt":0.4278086637722961,"score_spread":0.3706818879708341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}