{"id":"W2188123616","doi":"10.1093/genetics/165.4.2181","title":"The Genetics of Adaptation: The Roles of Pleiotropy, Stabilizing Selection and Drift in Shaping the Distribution of Bidirectional Fixed Mutational Effects","year":2003,"lang":"en","type":"article","venue":"Genetics","topic":"Genetic Mapping and Diversity in Plants and Animals","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pleiotropy; Biology; Genetics; Fixation (population genetics); Selection (genetic algorithm); Mutation; Phenotype; Point mutation; Evolutionary biology; Neutral mutation; Quantitative trait locus; Genetic drift; Directional selection; Genetic variation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001366674,0.0003733681,0.0004140015,0.0008488811,0.0004857592,0.001103987,0.0003632249,0.0005050075,0.001195022],"category_scores_gemma":[0.003422769,0.0001823682,0.0004112533,0.0007485521,0.001381127,0.0009770693,0.0006563591,0.0005791776,0.0001650176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006332893,"about_ca_system_score_gemma":0.0003971487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007049956,"about_ca_topic_score_gemma":0.001043995,"domain_scores_codex":[0.9995856,0.0001829759,0.00001779589,0.00008649923,0.00008379132,0.00004345843],"domain_scores_gemma":[0.9990507,0.0005844723,0.0001720383,0.00008396465,0.00005111164,0.00005768352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005194845,0.0001347234,0.164694,0.0004098879,0.0003868229,0.001049419,0.001482108,0.1129996,0.221753,0.2802596,0.0007214914,0.2155898],"study_design_scores_gemma":[0.00009295866,0.0004614979,0.2249078,0.0001075996,0.0002867414,0.003406216,0.0008751205,0.2671896,0.01867678,0.4774559,0.006347713,0.0001920889],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8117753,0.002597934,0.1796702,0.0007622762,0.00003325455,0.0000275732,0.00008467458,0.0001003487,0.004948511],"genre_scores_gemma":[0.9921904,0.0005439111,0.006566342,0.00004526434,0.00002652428,0.00001526497,0.0000254643,0.00001774145,0.0005691122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366674,"threshold_uncertainty_score":0.007227778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484865448916477,"score_gpt":0.2264073132272139,"score_spread":0.2115586587380491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}