{"id":"W2188123616","doi":"10.1093/genetics/165.4.2181","title":"The Genetics of Adaptation: The Roles of Pleiotropy, Stabilizing Selection and Drift in Shaping the Distribution of Bidirectional Fixed Mutational Effects","year":2003,"lang":"en","type":"article","venue":"Genetics","topic":"Genetic Mapping and Diversity in Plants and Animals","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pleiotropy; Biology; Genetics; Fixation (population genetics); Selection (genetic algorithm); Mutation; Phenotype; Point mutation; Evolutionary biology; Neutral mutation; Quantitative trait locus; Genetic drift; Directional selection; Genetic variation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003086928,0.00007307769,0.00008591956,0.00001650712,0.0001449568,0.00001052474,0.00009367469,0.00005732352,0.000002232086],"category_scores_gemma":[0.0001390412,0.00004584956,0.00003965896,0.0001045681,0.0001499099,0.000001484542,0.00003501753,0.00005129669,1.122942e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005077871,"about_ca_system_score_gemma":0.0000683688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001417796,"about_ca_topic_score_gemma":0.0001837976,"domain_scores_codex":[0.9992945,0.0001311063,0.0002112873,0.0001131518,0.0001467108,0.0001032108],"domain_scores_gemma":[0.9994691,0.0001367359,0.0001395739,0.0001062155,0.0001325989,0.00001578274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001672662,0.0001569151,0.1266211,0.0001829423,0.000204386,5.588624e-7,0.001627204,0.05848654,0.7887065,0.005306252,0.0005044708,0.01803578],"study_design_scores_gemma":[0.0009228306,0.0005525085,0.2845904,0.00006657605,0.00009001691,0.0000271308,0.002789536,0.01187176,0.6873124,0.001113854,0.01046635,0.00019665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930338,0.003812542,0.002766614,0.00008113583,0.00006487394,0.0001409201,0.00003114947,0.000001425357,0.00006752639],"genre_scores_gemma":[0.9984362,0.0008704668,0.0005975458,0.0000127991,0.00002944965,0.000004790194,0.00002698286,0.000003715792,0.00001804286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1579693,"threshold_uncertainty_score":0.1869691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484865448916477,"score_gpt":0.2264073132272139,"score_spread":0.2115586587380491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}