{"id":"W2188252236","doi":"10.1111/bph.13398","title":"Integrating the GPCR transactivation‐dependent and biased signalling paradigms in the context of PAR1 signalling","year":2015,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Transactivation; G protein-coupled receptor; Signalling; Receptor; Cell biology; Biology; Second messenger system; Functional selectivity; Context (archaeology); Signal transduction; Agonist; G protein; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005905959,0.0005027978,0.0008468667,0.0005198578,0.0003606275,0.001693111,0.0007300413,0.001213161,0.002427548],"category_scores_gemma":[0.0001912755,0.0002572724,0.0006439135,0.0004085684,0.0009005844,0.001891175,0.0009165092,0.003654623,0.001292149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008209656,"about_ca_system_score_gemma":0.0003540765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002904941,"about_ca_topic_score_gemma":0.0005115823,"domain_scores_codex":[0.9997216,0.00005757903,0.00001665881,0.00005275763,0.00008352227,0.00006779804],"domain_scores_gemma":[0.9999368,0.00002170154,0.00001057939,0.000004952885,0.00001274236,0.0000131379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005214699,0.0001586098,0.0004889694,0.009062981,0.0001352591,0.002558369,0.001169074,0.003165793,0.4995951,0.2474304,0.01741904,0.2182949],"study_design_scores_gemma":[0.0000433603,0.001148673,0.002191368,0.0009134111,0.000151457,0.007910371,0.0004796644,0.004698991,0.1044777,0.04744677,0.8303861,0.0001521751],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04048416,0.8218498,0.06271433,0.01487916,0.00567479,0.0001939902,0.0005014333,0.0005983593,0.05310405],"genre_scores_gemma":[0.1424501,0.8072065,0.02247229,0.006422271,0.005610683,0.0001646071,0.0004151405,0.0000828951,0.01517547],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002427548,"threshold_uncertainty_score":0.008120954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04426172375151591,"score_gpt":0.3288489701923102,"score_spread":0.2845872464407943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}