{"id":"W2188378454","doi":"","title":"The use of 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin (AMMC) as a specific CYP2D6 probe in human liver microsomes.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Metabolite; Microsome; Demethylation; Chemistry; Cytochrome P450; Metabolism; CYP2D6; Microsoma; Chromatography; Enzyme; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003625273,0.0003494466,0.0002525272,0.0002180727,0.0002475902,0.0002429665,0.0002413968,0.000717884,0.0008572376],"category_scores_gemma":[0.0004072411,0.0001830204,0.0002893854,0.0002266815,0.0003365401,0.000333996,0.0002138443,0.0006931327,0.0005498428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005129928,"about_ca_system_score_gemma":0.0002403439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086828,"about_ca_topic_score_gemma":0.001353918,"domain_scores_codex":[0.999617,0.0001510631,0.00001473479,0.0001125652,0.00007478106,0.00002973632],"domain_scores_gemma":[0.9997597,0.00007872531,0.00006084383,0.00004641056,0.00003178134,0.00002245707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004575668,0.00000979529,0.0002361926,0.00004027694,0.000008342356,0.00003498974,0.000009043778,0.00006007304,0.9968013,0.00007699244,0.00003842706,0.002638891],"study_design_scores_gemma":[0.000006947175,0.0001535091,0.002001207,0.000002499845,0.00001150445,0.0003450151,0.000006784548,0.0004216808,0.9944052,0.00003814571,0.002603406,0.000004053712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8392299,0.02962191,0.1208153,0.001265997,0.0001756276,0.0002777214,0.0008735885,0.0005256498,0.007214233],"genre_scores_gemma":[0.9630672,0.005518329,0.02568907,0.0002099079,0.00006437772,0.0001123164,0.001118329,0.00002499568,0.00419538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086828,"threshold_uncertainty_score":0.003722012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2315267573074949,"score_gpt":0.3954723274777223,"score_spread":0.1639455701702275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}