{"id":"W2188444587","doi":"10.1074/jbc.m115.678672","title":"Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Housefly; Pyrethroid; Chemistry; Sodium channel; Sodium; Stereochemistry; Docking (animal); Indoor residual spraying; Binding site; Pesticide; Biochemistry; Biology; Larva; Ecology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000157777,0.0002582156,0.0001875129,0.000133434,0.0001965307,0.0002859941,0.0003692334,0.0005395986,0.0009564324],"category_scores_gemma":[0.0003557673,0.0002220263,0.0002836867,0.0001103155,0.0003366508,0.0004578208,0.000380284,0.0003750769,0.0001837635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002315475,"about_ca_system_score_gemma":0.0001876909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007976997,"about_ca_topic_score_gemma":0.0009976631,"domain_scores_codex":[0.9997999,0.00003020155,0.00001319077,0.00005131452,0.00007605204,0.00002931525],"domain_scores_gemma":[0.9998142,0.00005038881,0.00006758064,0.0000119618,0.00002587965,0.00003000681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003926745,0.00005142324,0.005039704,0.0001819584,0.00002925379,0.0004270893,0.00004857246,0.002203691,0.9881115,0.0008425352,0.0001551385,0.002516443],"study_design_scores_gemma":[0.0002335911,0.0007274447,0.04171341,0.00004391367,0.0001623386,0.002382798,0.0002759314,0.07681766,0.8734577,0.001652129,0.002473109,0.00006006816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936559,0.001087363,0.003665534,0.0001699971,0.00002118074,0.000007275368,0.00007067098,0.0000544195,0.001267535],"genre_scores_gemma":[0.9981318,0.0004893281,0.001064196,0.00005533606,0.000003587054,0.000004196127,0.00008779421,0.000003803988,0.0001599656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009564324,"threshold_uncertainty_score":0.003199637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1617497405632036,"score_gpt":0.3264648206426332,"score_spread":0.1647150800794296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}