{"id":"W2188444587","doi":"10.1074/jbc.m115.678672","title":"Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Housefly; Pyrethroid; Chemistry; Sodium channel; Sodium; Stereochemistry; Docking (animal); Indoor residual spraying; Binding site; Pesticide; Biochemistry; Biology; Larva; Ecology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009764566,0.0001807692,0.0002915197,0.00005769172,0.00004543515,0.00003150594,0.0001853561,0.0003780437,0.00002184953],"category_scores_gemma":[0.002698135,0.0001378379,0.0002279901,0.0001300033,0.00006901512,0.00001564796,0.00006135717,0.0001508453,0.000001482248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007043139,"about_ca_system_score_gemma":0.0001554863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001363889,"about_ca_topic_score_gemma":9.369713e-7,"domain_scores_codex":[0.9987281,0.00003984026,0.0005124949,0.0002703741,0.0001613262,0.0002878652],"domain_scores_gemma":[0.9987426,0.0001578133,0.0003550031,0.0001284707,0.0004345028,0.0001815483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002247728,0.0000978912,0.002285268,0.00005414163,0.00003170651,0.00000546186,0.00004263366,0.0003154965,0.9911832,0.000006113504,0.003150986,0.0005793808],"study_design_scores_gemma":[0.00310102,0.001624407,0.0004238639,0.00009273132,0.00002340921,0.0001831098,0.0003198541,0.000448032,0.9768477,0.0003553862,0.01628948,0.0002909936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931424,0.001504798,0.003978106,0.0003945107,0.0006435855,0.000229259,0.00002015508,0.000008095975,0.00007911397],"genre_scores_gemma":[0.9953178,0.0001893563,0.001030621,0.0001313986,0.002599432,0.0000331319,0.000102965,0.00001441815,0.0005808941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01433548,"threshold_uncertainty_score":0.5620866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1617497405632036,"score_gpt":0.3264648206426332,"score_spread":0.1647150800794296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}