{"id":"W2188661282","doi":"10.1101/gad.266056.115","title":"REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation in <i>Caenorhabditis elegans</i>","year":2015,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Wellcome; Canadian Institutes of Health Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of British Columbia; Wellcome Trust; Francis Crick Institute; European Research Council; National Institutes of Health; Cancer Research UK; Magee-Womens Research Institute; Medical Research Council","keywords":"Biology; Caenorhabditis elegans; Genetics; Meiosis; Genetic screen; Bivalent (engine); Cyclin-dependent kinase; Chromosomal crossover; Gene; Mutant; Cell biology; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003607668,0.0002116602,0.0001987856,0.00008725825,0.00008326933,0.00008186295,0.00009433696,0.0001620563,0.000004815745],"category_scores_gemma":[0.00001878662,0.0002231165,0.00002056584,0.0001120156,0.00007643316,0.00002443361,0.0001052585,0.0000952314,0.000004716284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009277259,"about_ca_system_score_gemma":0.0001544938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001260107,"about_ca_topic_score_gemma":0.001804384,"domain_scores_codex":[0.9986817,0.00004586813,0.000370052,0.000389346,0.0001811768,0.0003318632],"domain_scores_gemma":[0.9995182,0.00000719217,0.00008499117,0.0001756164,0.00006925235,0.0001448016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002792722,0.000635937,0.2291311,0.0008063307,0.0003011098,0.0001425439,0.02027441,0.006113729,0.5988201,0.0002447181,0.005641758,0.1350956],"study_design_scores_gemma":[0.01278768,0.0006262196,0.2235646,0.0001589634,0.00008746253,0.0005049552,0.001732115,0.0006140478,0.6582944,0.0007586989,0.09947741,0.001393521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925354,0.002425797,0.004104154,0.0001940744,0.0002360878,0.0002965664,0.00001219166,0.00001119871,0.0001845439],"genre_scores_gemma":[0.9966221,0.0009625338,0.001702132,0.0001466306,0.00006055398,0.00002219617,0.0002565543,0.0000197026,0.0002075965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.133702,"threshold_uncertainty_score":0.9098426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508656677814204,"score_gpt":0.2214306179663962,"score_spread":0.2063440511882541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}