{"id":"W2188873428","doi":"10.1016/j.cell.2015.10.065","title":"A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":570,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; Krembil Foundation","keywords":"Ciliogenesis; Centrosome; Cilium; Centriole; Biology; Motile cilium; Cell biology; Microtubule; Basal body; Ciliopathies; Computational biology; Phenotype; Flagellum; Genetics; Cell; Cell cycle; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004361283,0.00006994218,0.00006111973,0.00001123418,0.00002360961,0.000007627575,0.0001483387,0.00004712523,0.00002206239],"category_scores_gemma":[0.00002854948,0.00005071766,0.00005651739,0.00003471037,0.00003785385,0.000001385821,0.00009565139,0.00004131476,0.00001297663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008196537,"about_ca_system_score_gemma":0.00005896748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009526522,"about_ca_topic_score_gemma":0.000009888321,"domain_scores_codex":[0.9995601,0.00003688283,0.0001011861,0.0001307814,0.00007400756,0.00009710469],"domain_scores_gemma":[0.9995705,0.000001291158,0.00006342548,0.0002456014,0.00005201717,0.0000672052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002806543,0.00006434838,0.0009392555,0.00001998345,0.000007250957,1.848683e-7,0.00005360474,0.00005315279,0.9949852,0.000001421222,0.003818959,0.00002859805],"study_design_scores_gemma":[0.0004765995,0.0001278228,0.001718196,0.00001594767,0.00001273892,0.000001773974,0.0003235753,0.00009263172,0.9837546,0.0000551412,0.01334873,0.00007224687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945447,0.0004514257,0.0001775819,0.00008201637,0.0001467244,0.0001597987,0.00001248926,0.000004642226,0.004420579],"genre_scores_gemma":[0.9956609,0.000004118352,0.00006454154,0.00004197927,0.00003377755,0.00000934741,0.00002715019,0.000008612739,0.004149546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01123058,"threshold_uncertainty_score":0.2068206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008076260797657369,"score_gpt":0.2435416593665533,"score_spread":0.235465398568896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}