{"id":"W2189024098","doi":"10.1038/ncomms9658","title":"Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Institut universitaire de cardiologie et de pneumologie de Québec; St. Paul's Hospital","funders":"National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; NIHR Cambridge Biomedical Research Centre; Cambridge Institute for Medical Research, University of Cambridge; Uppsala Universitet; Medical Research Council; Fonds de Recherche du Québec - Santé; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Turun Yliopistollinen Keskussairaala; Healthway; Tays; Svenska Läkaresällskapet; Sydäntutkimussäätiö; Emil Aaltosen Säätiö; Hrvatska Zaklada za Znanost; Vetenskapsrådet; Juho Vainion Säätiö; Paavo Nurmen Säätiö; Hjärt-Lungfonden; Oulun Yliopisto; Suomen Kulttuurirahasto; Kuopion Yliopistollinen Sairaala; University of Bristol; European Commission; Pfizer; Münchner Zentrum für Gesundheitswissenschaften; Stiftelsen för Strategisk Forskning; University of Oxford; Academy of Finland; European Regional Development Fund; King's College London; Directorate for Biological Sciences; Imperial College London; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Leicester; Foundation for Cardiovascular Research; Age UK; British Heart Foundation; Bundesministerium für Bildung und Forschung; Uppsala Multidisciplinary Center for Advanced Computational Science; University of Edinburgh; Centre for Cognitive Ageing and Cognitive Epidemiology; National Eye Institute; Biocenter, University of Oulu; National Institute for Health and Care Research; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Wellcome Trust; University College London; Cancer Research UK; East Midlands Development Agency; Michael Smith Health Research BC; Juvenile Diabetes Research Foundation International; Université Laval","keywords":"Imputation (statistics); Genome-wide association study; Vital capacity; 1000 Genomes Project; Lung function; Genome; Genotype; Pulmonary function testing; Biology; Medicine; Lung; Computational biology; Genetics; Internal medicine; Single-nucleotide polymorphism; Statistics; Gene; Mathematics; Missing data","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002619195,0.0005781612,0.001020738,0.0009632317,0.00043638,0.00107169,0.001077785,0.0008845267,0.003657072],"category_scores_gemma":[0.006903538,0.000355522,0.001377725,0.002323691,0.0002985559,0.0003433547,0.0008490527,0.0007607916,0.0006592979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002834544,"about_ca_system_score_gemma":0.0003860851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004224442,"about_ca_topic_score_gemma":0.004628262,"domain_scores_codex":[0.9983782,0.0003783358,0.0001994096,0.0006661181,0.0001809965,0.0001970586],"domain_scores_gemma":[0.9978082,0.001034044,0.0004699984,0.0004455306,0.0001553237,0.00008697692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001749908,0.0000739001,0.9437144,0.0002482503,0.002103534,0.00161882,0.0001932623,0.003021398,0.01375361,0.000724559,0.003705016,0.02909318],"study_design_scores_gemma":[0.0003748344,0.0002212569,0.9779755,0.00007314848,0.001144265,0.00214715,0.0001201043,0.006726262,0.002726466,0.00157776,0.006872545,0.00004070359],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665736,0.001345286,0.009347103,0.0001855009,0.00003676628,0.00004438499,0.02145618,0.0001652183,0.0008459318],"genre_scores_gemma":[0.9566496,0.000424832,0.006908912,0.000215243,0.00002291168,0.0001013705,0.03466649,0.0000663927,0.0009441467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004224442,"threshold_uncertainty_score":0.01385176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1219036867282651,"score_gpt":0.3979350807843533,"score_spread":0.2760313940560882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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