{"id":"W2189024098","doi":"10.1038/ncomms9658","title":"Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Institut universitaire de cardiologie et de pneumologie de Québec; St. Paul's Hospital","funders":"National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; NIHR Cambridge Biomedical Research Centre; Cambridge Institute for Medical Research, University of Cambridge; Uppsala Universitet; Medical Research Council; Fonds de Recherche du Québec - Santé; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Turun Yliopistollinen Keskussairaala; Healthway; Tays; Svenska Läkaresällskapet; Sydäntutkimussäätiö; Emil Aaltosen Säätiö; Hrvatska Zaklada za Znanost; Vetenskapsrådet; Juho Vainion Säätiö; Paavo Nurmen Säätiö; Hjärt-Lungfonden; Oulun Yliopisto; Suomen Kulttuurirahasto; Kuopion Yliopistollinen Sairaala; University of Bristol; European Commission; Pfizer; Münchner Zentrum für Gesundheitswissenschaften; Stiftelsen för Strategisk Forskning; University of Oxford; Academy of Finland; European Regional Development Fund; King's College London; Directorate for Biological Sciences; Imperial College London; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Leicester; Foundation for Cardiovascular Research; Age UK; British Heart Foundation; Bundesministerium für Bildung und Forschung; Uppsala Multidisciplinary Center for Advanced Computational Science; University of Edinburgh; Centre for Cognitive Ageing and Cognitive Epidemiology; National Eye Institute; Biocenter, University of Oulu; National Institute for Health and Care Research; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Wellcome Trust; University College London; Cancer Research UK; East Midlands Development Agency; Michael Smith Health Research BC; Juvenile Diabetes Research Foundation International; Université Laval","keywords":"Imputation (statistics); Genome-wide association study; Vital capacity; 1000 Genomes Project; Lung function; Genome; Genotype; Pulmonary function testing; Biology; Medicine; Lung; Computational biology; Genetics; Internal medicine; Single-nucleotide polymorphism; Statistics; Gene; Mathematics; Missing data","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003709035,0.0002076623,0.0002731942,0.0002073071,0.0002608642,0.00007916558,0.0007073999,0.0003372918,0.0001909658],"category_scores_gemma":[0.0003502234,0.0001946105,0.00009717143,0.0009688815,0.000178068,0.0004549565,0.0004071886,0.001268585,0.0001770228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006331432,"about_ca_system_score_gemma":0.001829995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005493113,"about_ca_topic_score_gemma":0.0001816132,"domain_scores_codex":[0.997977,0.0002826766,0.0003608471,0.0003911416,0.0006533721,0.0003349568],"domain_scores_gemma":[0.9962344,0.0002482858,0.0001584099,0.002060681,0.001031533,0.0002666613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.002796754,0.002887024,0.07322723,0.0008386124,0.002080133,0.00009150556,0.01487867,0.0002928141,0.0115953,0.108499,0.613302,0.169511],"study_design_scores_gemma":[0.006052119,0.0004338164,0.5478733,0.0003517109,0.001138397,0.0001496883,0.006804074,0.006509386,0.0007672911,0.01304624,0.4159246,0.0009494796],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2256174,0.3817688,0.009362896,0.04641162,0.002030233,0.01184263,0.0005227185,0.001805683,0.3206381],"genre_scores_gemma":[0.9858661,0.0008115201,0.003954024,0.0004489183,0.0002490807,0.0001468608,0.001507304,0.00004383253,0.006972409],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7602487,"threshold_uncertainty_score":0.7935985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1219036867282651,"score_gpt":0.3979350807843533,"score_spread":0.2760313940560882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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