{"id":"W2189041637","doi":"10.3899/jrheum.150088","title":"The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-β and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist","year":2015,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Transforming growth factor; SMAD; Endothelin receptor antagonist; Endothelin 1; Medicine; Fibroblast; Transforming growth factor beta; Myofibroblast; Cancer research; Fibrosis; Mesenchymal stem cell; Endocrinology; Internal medicine; Endothelin receptor; Receptor; Biology; Cell culture; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001192542,0.0002952501,0.0007722719,0.0001591993,0.0002284887,0.00005667831,0.0001812577,0.0002567212,0.00002289933],"category_scores_gemma":[0.0001841471,0.0001617032,0.0001301231,0.0001613386,0.0003467525,0.0001500302,0.00002475435,0.0005273853,0.000004962447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001103723,"about_ca_system_score_gemma":0.0001941249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000520593,"about_ca_topic_score_gemma":0.0000226217,"domain_scores_codex":[0.9972498,0.0005419009,0.001117799,0.0002213179,0.0004564095,0.000412773],"domain_scores_gemma":[0.9981486,0.0006162693,0.0005089939,0.0001955917,0.000199481,0.0003310925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002664063,0.0001795685,0.02831377,0.0001881973,0.0004379323,0.00001400889,0.01362317,7.425379e-7,0.9474833,0.00008542577,0.003981662,0.003028136],"study_design_scores_gemma":[0.08487665,0.006417096,0.003831465,0.0162714,0.002834554,0.1466483,0.1196019,0.0008478126,0.6115673,0.0005329897,0.004549182,0.002021332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676687,0.02310529,0.00005440048,0.007939368,0.0003737087,0.0005072539,0.0002969159,0.00001885736,0.00003554134],"genre_scores_gemma":[0.9575703,0.04183507,0.00002116943,0.000381994,0.00003129469,0.0000117381,0.000007288319,0.0000360911,0.000105046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.335916,"threshold_uncertainty_score":0.6594063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02842770050399564,"score_gpt":0.2523378574081633,"score_spread":0.2239101569041677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}