{"id":"W2189041637","doi":"10.3899/jrheum.150088","title":"The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-β and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist","year":2015,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Transforming growth factor; SMAD; Endothelin receptor antagonist; Endothelin 1; Medicine; Fibroblast; Transforming growth factor beta; Myofibroblast; Cancer research; Fibrosis; Mesenchymal stem cell; Endocrinology; Internal medicine; Endothelin receptor; Receptor; Biology; Cell culture; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399244,0.0002771917,0.0002147661,0.0001407339,0.0001124779,0.0001458498,0.0001020137,0.0001524235,0.001713937],"category_scores_gemma":[0.0001195891,0.00009906408,0.0001898892,0.00006516443,0.0001319339,0.00009082006,0.0001051684,0.0004042583,0.0002341823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007903721,"about_ca_system_score_gemma":0.00009931776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001308136,"about_ca_topic_score_gemma":0.0002681518,"domain_scores_codex":[0.9999175,0.00002087044,0.00000965192,0.0000113609,0.00001844896,0.00002214578],"domain_scores_gemma":[0.9999287,0.0000135242,0.00002363993,0.000007006206,0.000008289568,0.00001878312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004379467,0.0001103995,0.0005592787,0.00006165608,0.00001207118,0.00008980527,0.000008861897,0.00002044081,0.9956934,0.00004081071,0.00003105316,0.002934102],"study_design_scores_gemma":[0.0001982756,0.002510641,0.04092157,0.00002251486,0.00008769627,0.001408467,0.00004435394,0.0008093426,0.9505381,0.00005324448,0.003400994,0.000004756267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942641,0.003644739,0.0008869087,0.00005512169,0.00002765963,0.00002001049,0.00004456497,0.00003418173,0.001022801],"genre_scores_gemma":[0.9966203,0.00118824,0.0008291947,0.00003968669,0.00001771547,0.00003844101,0.0001346424,0.000003524787,0.001128186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713937,"threshold_uncertainty_score":0.005733669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02842770050399564,"score_gpt":0.2523378574081633,"score_spread":0.2239101569041677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}