{"id":"W2189115178","doi":"10.1016/j.febslet.2015.10.020","title":"Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b","year":2015,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Fonds de Recherche du Québec - Santé","keywords":"Pars compacta; Substantia nigra; Biology; Transcription factor; Floor plate; Homeobox; Dopaminergic; Neuroscience; Ventral tegmental area; Midbrain; Parkinson's disease; Cell biology; Embryonic stem cell; Cell fate determination; Genetics; Dopamine; Disease; Internal medicine; Gene; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002198173,0.0002512667,0.000351233,0.00006956624,0.00006592872,0.00003574265,0.0002195495,0.00008277011,0.000002760974],"category_scores_gemma":[0.00003796758,0.000173547,0.00012661,0.00007295432,0.0001706983,0.000007412959,0.0001100204,0.0001713607,0.000001619085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000197063,"about_ca_system_score_gemma":0.00009889713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000122224,"about_ca_topic_score_gemma":0.000004101292,"domain_scores_codex":[0.9986428,0.0002068575,0.0002749921,0.0003890134,0.0002310935,0.000255213],"domain_scores_gemma":[0.9993074,0.00002407061,0.0001702717,0.0002714579,0.00005776961,0.000169057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001653597,0.0001155642,0.0008947709,0.01827135,0.0002272467,0.00004065902,0.0005272342,0.00003771386,0.162001,0.00001017246,0.01111238,0.8065966],"study_design_scores_gemma":[0.0002482595,0.00006420853,0.0005193968,0.0004563265,0.0001653035,0.000008608815,0.00003359723,0.0000532444,0.0009941572,0.00001750445,0.9971688,0.0002706407],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0546292,0.9440451,0.0002071326,0.000283774,0.00008301278,0.0005205558,0.0001849114,0.000005866344,0.00004041328],"genre_scores_gemma":[0.01970784,0.9794064,0.00002965999,0.0001511316,0.00006195909,0.00003381819,0.0002790212,0.00004096378,0.0002891941],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9860564,"threshold_uncertainty_score":0.7077043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902452978275277,"score_gpt":0.2748219265170885,"score_spread":0.2557973967343358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}