{"id":"W2189115178","doi":"10.1016/j.febslet.2015.10.020","title":"Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b","year":2015,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Fonds de Recherche du Québec - Santé","keywords":"Pars compacta; Substantia nigra; Biology; Transcription factor; Floor plate; Homeobox; Dopaminergic; Neuroscience; Ventral tegmental area; Midbrain; Parkinson's disease; Cell biology; Embryonic stem cell; Cell fate determination; Genetics; Dopamine; Disease; Internal medicine; Gene; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003122789,0.0005953736,0.0008444448,0.001219285,0.0002799618,0.00084414,0.000556876,0.0008282603,0.00186248],"category_scores_gemma":[0.000373661,0.0002080604,0.000254591,0.001479523,0.0005802753,0.001127139,0.0005471712,0.001170274,0.001323164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006207633,"about_ca_system_score_gemma":0.0007676507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009041585,"about_ca_topic_score_gemma":0.001265385,"domain_scores_codex":[0.9998945,0.00001680982,0.00001511208,0.00002523966,0.00003667708,0.00001162013],"domain_scores_gemma":[0.9998798,0.00005044881,0.00001535222,0.000005157486,0.00003379281,0.00001531307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000618496,0.00003296425,0.0002366228,0.01110862,0.00005378262,0.0003183236,0.0001026037,0.0003687291,0.007513538,0.007817938,0.0234447,0.9489402],"study_design_scores_gemma":[0.000006794995,0.0000432197,0.0009123536,0.001053786,0.0000423239,0.001286267,0.0000736125,0.00008447493,0.00101543,0.002624343,0.9928439,0.00001344316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002142466,0.9978141,0.000191575,0.0002802823,0.0001851132,0.000002085686,0.00001251195,0.000006675145,0.001293487],"genre_scores_gemma":[0.001272093,0.9971557,0.000238176,0.0001854183,0.000141106,0.000005411427,0.00002248845,0.000001729167,0.0009779303],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00186248,"threshold_uncertainty_score":0.006230593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902452978275277,"score_gpt":0.2748219265170885,"score_spread":0.2557973967343358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}