{"id":"W2189448670","doi":"10.1016/j.bmc.2015.09.039","title":"Ring substitution influences oxidative cyclisation and reactive metabolite formation of nordihydroguaiaretic acid analogues","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Nordihydroguaiaretic acid; Catechol; Quinone; Stereochemistry; Electrophilic substitution; Metabolite; Lignan; Intramolecular force; Polyphenol; Phenols; Electrophile; Antioxidant; Organic chemistry; Lipoxygenase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359285,0.0001571352,0.0002091326,0.00002954904,0.00005164988,0.00001240297,0.0001086547,0.0001574101,0.000005530657],"category_scores_gemma":[0.0003099086,0.0001331682,0.00003883881,0.0001051175,0.0002195505,0.00003097434,0.0000559639,0.0000881789,0.000001670892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003592218,"about_ca_system_score_gemma":0.0001048688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005007786,"about_ca_topic_score_gemma":0.0000104415,"domain_scores_codex":[0.9990711,0.00005133541,0.0002433723,0.0002540162,0.0002203387,0.0001598051],"domain_scores_gemma":[0.9993194,0.00001683825,0.0002312505,0.0001718243,0.0001407336,0.0001199572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009104118,0.00003288029,0.001828778,0.00005606246,0.00003968594,0.000001714088,0.0002626187,0.000001249146,0.9967253,0.00001758619,0.00002183983,0.0009212879],"study_design_scores_gemma":[0.0003920329,0.00008183318,0.006121059,0.00005359384,0.00007382969,0.00005772011,0.001052052,0.00007631363,0.9914662,0.00004558173,0.0004363725,0.000143385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960568,0.001616496,0.001486198,0.00006003599,0.00004645336,0.00009231972,0.00004797091,0.00001256386,0.0005811951],"genre_scores_gemma":[0.9990996,0.0002381857,0.0001874035,0.00002851724,0.0001639607,0.000006962098,0.0002530483,0.000007877159,0.00001442192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00525903,"threshold_uncertainty_score":0.5430441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02282069247342259,"score_gpt":0.2444707461782563,"score_spread":0.2216500537048338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}