{"id":"W2189626932","doi":"10.1007/s00239-015-9702-z","title":"Searching for a DNAzyme Version of the Leadzyme","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular Evolution","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deoxyribozyme; Ribozyme; Nucleotide; RNA; Biology; DNA; Ribonucleotide; Enzyme; Hairpin ribozyme; Deoxyribonucleotides; Biochemistry; Oligonucleotide; VS ribozyme; Stereochemistry; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004561313,0.0005559402,0.000878147,0.0006087216,0.0003251974,0.001478525,0.0009212536,0.001211405,0.005497274],"category_scores_gemma":[0.00212299,0.0003576659,0.0007447887,0.0009026724,0.0003119201,0.0007696801,0.000482844,0.001562406,0.002192906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004030927,"about_ca_system_score_gemma":0.0005432208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003984441,"about_ca_topic_score_gemma":0.0007401786,"domain_scores_codex":[0.9995983,0.0000413757,0.00003233746,0.0001620468,0.0001085161,0.00005743133],"domain_scores_gemma":[0.9992718,0.0002181155,0.0001273828,0.0001106656,0.0001386211,0.0001334567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005659692,0.0001197538,0.003797378,0.0002724169,0.000062318,0.001026277,0.00008743338,0.0004690586,0.9683905,0.001083499,0.0005300537,0.02359539],"study_design_scores_gemma":[0.0001674277,0.001040758,0.005065399,0.00004309069,0.00016884,0.003111242,0.0002666546,0.00394099,0.9746323,0.001099773,0.01041797,0.00004551389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9071007,0.001595941,0.07926153,0.001533418,0.0004566206,0.0002506277,0.002330596,0.001053908,0.006416582],"genre_scores_gemma":[0.9174685,0.0006789557,0.0661129,0.0006339213,0.00004540433,0.00009038621,0.004781761,0.0002400833,0.009948141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005497274,"threshold_uncertainty_score":0.01839024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01325011438753308,"score_gpt":0.2830714689594042,"score_spread":0.2698213545718711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}