{"id":"W2189797784","doi":"10.1182/asheducation-2015.1.565","title":"Treatment of Langerhans cell histiocytosis: role of BRAF/MAPK inhibition","year":2015,"lang":"en","type":"article","venue":"Hematology","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Vemurafenib; Langerhans cell histiocytosis; Cancer research; Medicine; V600E; MAPK/ERK pathway; Melanoma; MEK inhibitor; Salvage therapy; Trametinib; Neuroblastoma RAS viral oncogene homolog; KRAS; Mutation; Oncology; Internal medicine; Cancer; Disease; Biology; Kinase; Chemotherapy; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002682531,0.0004158936,0.0004203876,0.0002948989,0.0001606516,0.0003007967,0.0002380791,0.0003340177,0.001132381],"category_scores_gemma":[0.0002288414,0.0000661231,0.0004456606,0.0001368367,0.0001360501,0.0002324804,0.0001645815,0.0006549849,0.0002992364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003591021,"about_ca_system_score_gemma":0.0002405355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003610399,"about_ca_topic_score_gemma":0.0009822708,"domain_scores_codex":[0.9999092,0.00002425732,0.000007601666,0.00001260037,0.00002372257,0.00002265805],"domain_scores_gemma":[0.9999286,0.00001472078,0.00001946151,0.000003484755,0.00001305254,0.00002065378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003524058,0.001327295,0.003128777,0.002340235,0.0004519822,0.001409017,0.0001135302,0.002294151,0.09724675,0.001880226,0.007943144,0.878341],"study_design_scores_gemma":[0.01034299,0.03698301,0.0926338,0.003478736,0.001951428,0.03019908,0.0004263574,0.01770234,0.1563258,0.009628139,0.640099,0.000229332],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.463891,0.5017737,0.004589313,0.00663957,0.0009326271,0.0002869811,0.0002603938,0.000401194,0.0212251],"genre_scores_gemma":[0.8886838,0.1018112,0.002625962,0.0013067,0.0005435589,0.0001358464,0.0001995992,0.00003766233,0.004655675],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001132381,"threshold_uncertainty_score":0.003788173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02289926937455022,"score_gpt":0.2668689695942609,"score_spread":0.2439697002197107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}