{"id":"W2189861011","doi":"10.1016/s0140-6736(15)01159-9","title":"Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial","year":2015,"lang":"en","type":"article","venue":"The Lancet","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":972,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"","keywords":"Voriconazole; Medicine; Clinical endpoint; Internal medicine; Population; Adverse effect; Clinical trial; Surgery; Gastroenterology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002327172,0.002248215,0.004601587,0.0004835392,0.000509147,0.001531358,0.001042814,0.002396114,0.008270914],"category_scores_gemma":[0.00225857,0.0007894258,0.004032152,0.0005006901,0.001743606,0.001436758,0.0005169981,0.004505415,0.001163928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001023079,"about_ca_system_score_gemma":0.0008343887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213642,"about_ca_topic_score_gemma":0.002806505,"domain_scores_codex":[0.9990352,0.0004707079,0.00006536853,0.0001689815,0.00007244985,0.0001873159],"domain_scores_gemma":[0.9989697,0.0003955431,0.0002203167,0.0001018705,0.00006190415,0.0002506831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9827884,0.001215206,0.0002612703,0.001000691,0.001541575,0.00004341352,0.00005256324,0.0002501213,0.00111631,0.0001870742,0.0006632995,0.01088013],"study_design_scores_gemma":[0.9772324,0.02026882,0.0007826,0.00006695154,0.0006843224,0.0000331148,0.00002244945,0.0001915197,0.0001286624,0.0002400128,0.0003375296,0.00001163364],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668574,0.02121787,0.00129914,0.001472093,0.001722435,0.002624097,0.001102528,0.000218683,0.003485805],"genre_scores_gemma":[0.98474,0.006093264,0.001469171,0.001226584,0.0006772372,0.001888921,0.0007339484,0.00003693204,0.00313412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008270914,"threshold_uncertainty_score":0.02766895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06051365071297336,"score_gpt":0.3374946320403873,"score_spread":0.2769809813274139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}