{"id":"W2189915593","doi":"10.15698/mic2015.12.243","title":"Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration","year":2015,"lang":"en","type":"article","venue":"Microbial Cell","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Muscular Dystrophy Association","keywords":"Neurodegeneration; Eukaryotic cell; Yeast; Protein folding; Neuroscience; Computational biology; Biology; Computer science; Cell; Cell biology; Biochemistry; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002150425,0.00008723178,0.00007759074,0.00001645037,0.00005199257,0.00002379375,0.0001867878,0.00006720587,0.000003951427],"category_scores_gemma":[0.00003650046,0.00006716043,0.00006648835,0.00005602092,0.00004097304,0.000002990902,0.000106194,0.00004903846,0.000004228365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008500627,"about_ca_system_score_gemma":0.0001064943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001651272,"about_ca_topic_score_gemma":0.00002109914,"domain_scores_codex":[0.9993515,0.00004573488,0.0001407727,0.0001938307,0.00009751607,0.0001706148],"domain_scores_gemma":[0.9994933,0.000005014701,0.00004300191,0.0002301405,0.0001833108,0.000045207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001457922,0.0000439027,0.00002376329,0.00002795564,0.000006013259,2.533851e-7,0.00005491583,0.01973909,0.9767127,0.00002066735,0.002357368,0.0008675954],"study_design_scores_gemma":[0.0004716238,0.0002394433,0.00001426484,0.000004535574,0.000007548887,0.000002985587,0.00003155158,0.004506118,0.9882872,0.00004637373,0.006304368,0.00008402248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753365,0.0004613049,0.02274343,0.0000754065,0.0001069641,0.0004989238,0.00005611194,0.000004398555,0.0007169438],"genre_scores_gemma":[0.9944462,0.00002920567,0.00412429,0.00006821001,0.0002515994,0.00005489661,0.0000563641,0.00002005203,0.0009491899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01910968,"threshold_uncertainty_score":0.2738723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04179572713958343,"score_gpt":0.2399876610927121,"score_spread":0.1981919339531286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}