{"id":"W2189925268","doi":"10.1371/journal.pone.0138936","title":"The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China; McGill University","keywords":"Oculopharyngeal muscular dystrophy; Heat shock protein; Hsp90; Mutant; Hsp90 inhibitor; Poly(A)-binding protein; Alanine; Heat shock; Cell biology; Hsp70; Mutant protein; Molecular biology; Biology; Biochemistry; Amino acid; Muscular dystrophy; Gene; Messenger RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009070244,0.0003072072,0.0001934041,0.0001356596,0.00008958293,0.000188617,0.0001881374,0.0001328963,0.0009965554],"category_scores_gemma":[0.00009660325,0.00009791081,0.0001839837,0.00009272453,0.0001821763,0.0001180038,0.0001584427,0.0003644419,0.0003438447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002575053,"about_ca_system_score_gemma":0.0001716296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003998042,"about_ca_topic_score_gemma":0.0006517876,"domain_scores_codex":[0.999935,0.00001153341,0.000006863311,0.00001308728,0.00001523404,0.00001819105],"domain_scores_gemma":[0.9999355,0.000009025855,0.00002884948,0.0000057811,0.000005009427,0.00001586232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009760084,0.00003006795,0.0001598642,0.00004118767,0.000009091515,0.00003780645,0.000006303384,0.00003281635,0.9986567,0.00004079721,0.00003608636,0.0008515812],"study_design_scores_gemma":[0.00001215568,0.0002096886,0.005929795,0.000007438553,0.00001625937,0.000249419,0.00001220581,0.0005842743,0.9916768,0.00002649956,0.001272909,0.00000251416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958175,0.001766741,0.001379016,0.00006386433,0.00001779799,0.00001162286,0.0001464411,0.00004731307,0.0007497346],"genre_scores_gemma":[0.9951246,0.001515431,0.001610868,0.00004146097,0.000007425996,0.00002350572,0.0004935369,0.00001272695,0.001170227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009965554,"threshold_uncertainty_score":0.003333807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05706484534366627,"score_gpt":0.2540681832704141,"score_spread":0.1970033379267479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}