{"id":"W2190063129","doi":"10.2967/jnumed.115.162339","title":"Dual-Receptor–Targeted Radioimmunotherapy of Human Breast Cancer Xenografts in Athymic Mice Coexpressing HER2 and EGFR Using <sup>177</sup>Lu- or <sup>111</sup>In-Labeled Bispecific Radioimmunoconjugates","year":2015,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Radioimmunotherapy; Trastuzumab; Biodistribution; DOTA; Cancer research; Chemistry; Epidermal growth factor; Clonogenic assay; Epidermal growth factor receptor; Molecular biology; Medicine; Cancer; Breast cancer; Receptor; Immunology; Apoptosis; Antibody; Internal medicine; Monoclonal antibody; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009960865,0.0003659233,0.001241966,0.0004090116,0.000114573,0.00002927795,0.0002418776,0.0002161109,0.0007820883],"category_scores_gemma":[0.0001396679,0.000275168,0.0001183485,0.0007556768,0.000606101,0.0002621954,0.00004350972,0.0009437483,0.000003667709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004597784,"about_ca_system_score_gemma":0.0002596897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003547391,"about_ca_topic_score_gemma":0.000005280959,"domain_scores_codex":[0.996986,0.0001548922,0.001451669,0.0003333911,0.0006100923,0.0004639364],"domain_scores_gemma":[0.9981016,0.0001824449,0.0006269054,0.000294548,0.0003452559,0.0004492743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.003355168,0.0005905033,0.004322654,0.0002726851,0.0002510425,0.0002230107,0.006484805,0.0009107903,0.9783632,0.00002495635,0.002319488,0.002881714],"study_design_scores_gemma":[0.2744932,0.01134049,0.08861868,0.05173089,0.004034914,0.0372193,0.09873921,0.1402628,0.1302631,0.0005271882,0.1583191,0.004451141],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819861,0.01234066,0.000008049208,0.005012644,0.00008434113,0.0003763678,0.00001899976,0.00002420157,0.000148656],"genre_scores_gemma":[0.9943607,0.002709993,0.00122729,0.0005178581,0.0009820454,0.000006226356,0.00001086815,0.00008464593,0.0001003397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8481001,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05920411847555834,"score_gpt":0.3546806014509069,"score_spread":0.2954764829753485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}