{"id":"W2190063129","doi":"10.2967/jnumed.115.162339","title":"Dual-Receptor–Targeted Radioimmunotherapy of Human Breast Cancer Xenografts in Athymic Mice Coexpressing HER2 and EGFR Using <sup>177</sup>Lu- or <sup>111</sup>In-Labeled Bispecific Radioimmunoconjugates","year":2015,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Radioimmunotherapy; Trastuzumab; Biodistribution; DOTA; Cancer research; Chemistry; Epidermal growth factor; Clonogenic assay; Epidermal growth factor receptor; Molecular biology; Medicine; Cancer; Breast cancer; Receptor; Immunology; Apoptosis; Antibody; Internal medicine; Monoclonal antibody; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001881232,0.0005140363,0.0003476914,0.000200679,0.000117626,0.0002303654,0.0003083707,0.000320192,0.0008327509],"category_scores_gemma":[0.00006052251,0.0001600778,0.0002120246,0.0001296334,0.0002125067,0.0001685736,0.0001354672,0.0005593501,0.0002846229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000331655,"about_ca_system_score_gemma":0.0002153351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000683332,"about_ca_topic_score_gemma":0.0007311253,"domain_scores_codex":[0.9998926,0.00001884621,0.000006622662,0.00002088346,0.00002507192,0.00003595698],"domain_scores_gemma":[0.9999421,0.000009768131,0.00001982172,0.000007999507,0.000006193625,0.00001414095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002614176,0.0001065366,0.000096139,0.0000227387,0.000006728717,0.00001847216,0.00001281264,0.00009447355,0.9982186,0.0000719013,0.00004660773,0.001043476],"study_design_scores_gemma":[0.00004329484,0.001153969,0.0008885002,0.000002391398,0.00002057736,0.0001219903,0.000006512469,0.0006067514,0.9959224,0.00001180277,0.00121958,0.000002166696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944326,0.001172326,0.001998666,0.00008622485,0.00003185413,0.00008486101,0.0002438767,0.000141566,0.001807964],"genre_scores_gemma":[0.9925314,0.0007847143,0.003353849,0.00004959408,0.00001532396,0.0000978059,0.0003786094,0.00003146895,0.002757191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008327509,"threshold_uncertainty_score":0.002785802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05920411847555834,"score_gpt":0.3546806014509069,"score_spread":0.2954764829753485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}