{"id":"W2190126170","doi":"10.1016/j.eururo.2015.11.025","title":"It Is Time to Harmonize the Design and Conduct of Clinical Trials in Metastatic Hormone-sensitive Prostate Cancer","year":2015,"lang":"en","type":"letter","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Docetaxel; Clinical trial; Prostate cancer; Oncology; Internal medicine; Population; Androgen deprivation therapy; Medical physics; Family medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01304967,0.0003174877,0.00190085,0.0002274326,0.00003435828,0.0000193364,0.0001905526,0.0001880058,0.0002711219],"category_scores_gemma":[0.00286734,0.0001779646,0.0001791764,0.0002102934,0.0004961274,0.00003054599,0.0001781233,0.001546846,0.0004498653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005791579,"about_ca_system_score_gemma":0.0006060622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005050964,"about_ca_topic_score_gemma":0.000002373542,"domain_scores_codex":[0.9858797,0.01139849,0.001278534,0.0006073205,0.0003615645,0.0004744082],"domain_scores_gemma":[0.9950296,0.003604326,0.0004623212,0.0004312352,0.0003025132,0.0001699645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003915225,0.00004936188,0.00009156864,0.00005367363,0.0006395708,0.00314296,0.001602522,0.000005292506,0.0005339278,2.554065e-7,0.9854238,0.004541823],"study_design_scores_gemma":[0.00601135,0.002979829,0.001481291,0.00008151925,0.0008378385,0.00009125586,0.00004984628,0.0001109407,0.0002342703,0.00003308066,0.9878877,0.0002010277],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.007612138,0.004900318,0.00003048174,0.9804936,0.0002032108,0.003250206,0.0002746131,0.00001997095,0.003215426],"genre_scores_gemma":[0.005052882,0.003091919,0.0005510067,0.9596221,0.001514544,0.0001314554,0.0001844872,0.000152179,0.02969944],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02648401,"threshold_uncertainty_score":0.7257186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3681301245879864,"score_gpt":0.4704107201319918,"score_spread":0.1022805955440053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}