{"id":"W2190323360","doi":"10.3389/fnagi.2015.00221","title":"Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly","year":2015,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; California Department of Public Health; Alzheimer's Association","keywords":"Fluid-attenuated inversion recovery; Hyperintensity; Medicine; Pittsburgh compound B; Internal medicine; Cardiology; Neuroimaging; White matter; Amyloid (mycology); Magnetic resonance imaging; Alzheimer's disease; Pathology; Disease; Psychiatry; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005007292,0.0003385551,0.0003357598,0.0004817264,0.000308291,0.0003306476,0.0002133983,0.0004139837,0.0008632939],"category_scores_gemma":[0.001965974,0.000239699,0.0003123132,0.0004728812,0.0002569183,0.0002881413,0.000366414,0.0004819372,0.0001567951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001022288,"about_ca_system_score_gemma":0.000204667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003824687,"about_ca_topic_score_gemma":0.00676828,"domain_scores_codex":[0.9997427,0.00005461741,0.00003520817,0.00006226182,0.00006996682,0.00003528141],"domain_scores_gemma":[0.9984828,0.0001883778,0.0008487069,0.0001236796,0.0001054463,0.0002510671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004852753,0.00005815129,0.9959208,0.00001405736,0.0001113806,0.0001753323,0.00006743506,0.00004227317,0.0009099658,0.0000144183,0.00006735304,0.002133667],"study_design_scores_gemma":[0.000003476485,0.00005381833,0.9996336,0.000001438567,0.00001857453,0.000120467,0.00001439764,0.00007313655,0.00003143126,0.00002519135,0.00002304867,0.00000149233],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990871,0.0003233919,0.0000839762,0.0000223,0.000006995945,0.000004760467,0.0001024005,0.000006461096,0.0003625161],"genre_scores_gemma":[0.9994924,0.0001082678,0.0001006936,0.00001539429,0.00002296205,0.000004175483,0.000109507,0.000001640494,0.0001448858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003824687,"threshold_uncertainty_score":0.007604837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02960145062339567,"score_gpt":0.2709126605308622,"score_spread":0.2413112099074665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}