{"id":"W2190323360","doi":"10.3389/fnagi.2015.00221","title":"Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly","year":2015,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; California Department of Public Health; Alzheimer's Association","keywords":"Fluid-attenuated inversion recovery; Hyperintensity; Medicine; Pittsburgh compound B; Internal medicine; Cardiology; Neuroimaging; White matter; Amyloid (mycology); Magnetic resonance imaging; Alzheimer's disease; Pathology; Disease; Psychiatry; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004044342,0.000115287,0.0002031667,0.0003654187,0.00006185009,0.0000626127,0.0001082823,0.00004206269,0.000007337449],"category_scores_gemma":[0.0002156442,0.00009189377,0.00001546064,0.0006121522,0.000196031,0.0002321635,0.00008764507,0.0003053992,0.00000403778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000896089,"about_ca_system_score_gemma":0.000103341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003783295,"about_ca_topic_score_gemma":0.00004916061,"domain_scores_codex":[0.9984412,0.00009724742,0.0001464634,0.0003948911,0.0005250211,0.0003952118],"domain_scores_gemma":[0.9995301,0.0000175953,0.0000511746,0.0001349139,0.00007594844,0.0001902278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005886229,0.0001311846,0.9954749,0.00000972051,0.000001734673,0.0003802446,0.000196047,0.000009320307,0.0004560713,7.605393e-7,0.002382378,0.0008987924],"study_design_scores_gemma":[0.002097066,0.0003131546,0.9942124,0.000241953,0.000009974584,0.0000605632,0.0008958176,0.00172982,0.0001775863,0.00005082192,0.0001069409,0.0001038324],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959686,0.00006592367,0.0006278576,0.001888323,0.0002320934,0.0002743457,0.000002587145,0.00002236498,0.0009178472],"genre_scores_gemma":[0.9962782,0.00001283332,0.0003743859,0.001636603,0.00001051714,0.00001273151,0.000003037416,0.00001216895,0.001659486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002275437,"threshold_uncertainty_score":0.3747319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02960145062339567,"score_gpt":0.2709126605308622,"score_spread":0.2413112099074665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}