{"id":"W2190822649","doi":"10.4049/jimmunol.1501028","title":"Class A Scavenger Receptor–Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"TRIF; Innate immune system; Biology; TLR3; Cell biology; Internalization; Signal transduction; RIG-I; RNA silencing; PI3K/AKT/mTOR pathway; Receptor; Toll-like receptor; RNA interference; RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002080832,0.0002400107,0.0002420482,0.0001765137,0.0001442996,0.000397945,0.0002217422,0.000267955,0.001056852],"category_scores_gemma":[0.0001425089,0.0001478038,0.0004531795,0.0001012361,0.0003028533,0.0002443071,0.000250435,0.0004825309,0.0006862447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002719051,"about_ca_system_score_gemma":0.0003405898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004490403,"about_ca_topic_score_gemma":0.0005116779,"domain_scores_codex":[0.9997167,0.00003823637,0.00003161516,0.00005728725,0.00009714243,0.00005898794],"domain_scores_gemma":[0.9997981,0.00002427288,0.0000679706,0.00005645089,0.00003058009,0.00002265603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000047124,0.00001624716,0.0002154661,0.00002281821,0.000004344262,0.00004875662,0.000008973681,0.00001482951,0.9987871,0.0001207415,0.00001645336,0.0006971559],"study_design_scores_gemma":[0.00002284029,0.0002239883,0.006155051,0.000008369228,0.00001574376,0.0006052658,0.00003713276,0.001029915,0.9885972,0.00009666231,0.003201262,0.000006464988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878845,0.001128695,0.007431867,0.0001068698,0.00002885501,0.00005753201,0.0003126379,0.0001239402,0.002925119],"genre_scores_gemma":[0.9915007,0.0005590533,0.003411901,0.00004190717,0.0000109903,0.00005544951,0.0009006101,0.00002603287,0.00349334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056852,"threshold_uncertainty_score":0.003535509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02272337994472705,"score_gpt":0.2640042257949625,"score_spread":0.2412808458502355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}