{"id":"W2190836745","doi":"10.1016/j.jaad.2015.09.001","title":"Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with difficult-to-treat nail and scalp psoriasis: Results of 2 phase III randomized, controlled trials (ESTEEM 1 and ESTEEM 2)","year":2015,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"LEO Pharma; Janssen Pharmaceuticals; Les Laboratories Pierre Fabre; Celgene; Amgen; Pfizer; Kyowa Hakko Kirin; Eli Lilly and Company","keywords":"Apremilast; Medicine; Psoriasis; Placebo; Scalp; Nail (fastener); Randomized controlled trial; Randomization; Internal medicine; Dermatology; Psoriasis Area and Severity Index; Surgery; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005968366,0.0009265826,0.002127748,0.0003540512,0.0002740384,0.000817095,0.0006112902,0.001273895,0.002769734],"category_scores_gemma":[0.00382303,0.0003877254,0.002022617,0.0004837688,0.0007113431,0.0006768394,0.0002312975,0.001668306,0.000280922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718341,"about_ca_system_score_gemma":0.0007906567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003855877,"about_ca_topic_score_gemma":0.00120585,"domain_scores_codex":[0.9985158,0.0009671242,0.0001368514,0.0001426457,0.0001582962,0.00007929839],"domain_scores_gemma":[0.9979795,0.0007852882,0.0006271662,0.0001037056,0.0001390776,0.0003652739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8588344,0.01237397,0.0048006,0.004004563,0.005676083,0.0001050146,0.0001270464,0.0005640729,0.007467191,0.0001682855,0.002025181,0.1038536],"study_design_scores_gemma":[0.9094689,0.0773579,0.009735714,0.0001621872,0.001382266,0.0001268528,0.00002567959,0.0002667584,0.0004409741,0.00008358753,0.0009323868,0.00001674299],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9169773,0.0717645,0.001262715,0.001455949,0.0005079926,0.004284888,0.0008160638,0.0001223543,0.002808285],"genre_scores_gemma":[0.9658759,0.02352422,0.002815974,0.001742129,0.0008121928,0.002765728,0.001313399,0.00002063084,0.001129888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005968366,"threshold_uncertainty_score":0.03156412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141852448562145,"score_gpt":0.2920159108673063,"score_spread":0.2705973863816848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}