{"id":"W2190836745","doi":"10.1016/j.jaad.2015.09.001","title":"Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with difficult-to-treat nail and scalp psoriasis: Results of 2 phase III randomized, controlled trials (ESTEEM 1 and ESTEEM 2)","year":2015,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"LEO Pharma; Janssen Pharmaceuticals; Les Laboratories Pierre Fabre; Celgene; Amgen; Pfizer; Kyowa Hakko Kirin; Eli Lilly and Company","keywords":"Apremilast; Medicine; Psoriasis; Placebo; Scalp; Nail (fastener); Randomized controlled trial; Randomization; Internal medicine; Dermatology; Psoriasis Area and Severity Index; Surgery; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001965143,0.0003354316,0.004957602,0.0003053017,0.00006175055,0.00001116111,0.0002925925,0.0002118586,0.000003563744],"category_scores_gemma":[0.001646544,0.0001715269,0.0002860211,0.0003049647,0.001025186,0.0001742274,0.0001013698,0.000320693,0.000001266368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003700721,"about_ca_system_score_gemma":0.0001298159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007842947,"about_ca_topic_score_gemma":0.0000123613,"domain_scores_codex":[0.9936068,0.003438737,0.002238076,0.000260149,0.0001476777,0.0003085382],"domain_scores_gemma":[0.9939901,0.001783303,0.003709693,0.0001751244,0.0002107359,0.0001309996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9350522,0.00147996,0.03137427,0.00002849992,0.001643436,0.00001940443,0.002308758,0.00002021821,0.006473852,0.00003683924,0.001259886,0.02030266],"study_design_scores_gemma":[0.9406931,0.002556621,0.01723937,0.0002487116,0.00214286,0.0006776273,0.001143215,0.000008862959,0.03461865,0.00007190314,0.0003365136,0.0002625507],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944888,0.002898727,0.00001180891,0.001267057,0.000240891,0.000973711,0.00008155335,0.000007120495,0.00003036072],"genre_scores_gemma":[0.9989828,0.0003380142,0.0003684743,0.0001832362,0.00003322678,0.00002437199,0.000008808399,0.00001672015,0.00004436908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0281448,"threshold_uncertainty_score":0.6994666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141852448562145,"score_gpt":0.2920159108673063,"score_spread":0.2705973863816848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}