{"id":"W2190856209","doi":"10.1016/j.celrep.2015.11.021","title":"Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canadian Institute for Advanced Research","funders":"National Science Foundation Graduate Research Fellowship Program; National Science Foundation; Cancer Research UK; National Cancer Institute; National Science Council; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"CRISPR; Glioblastoma; Wee1; Genome editing; Biology; Redundancy (engineering); Genome; Stem cell; Computational biology; Genetics; Gene; Cancer research; Computer science; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672697,0.0004116631,0.0003666301,0.0003776664,0.0001532144,0.0003373921,0.0003182164,0.0002986211,0.001544912],"category_scores_gemma":[0.0001721861,0.0001834963,0.0002972811,0.0002247794,0.0002160411,0.0001157426,0.0002994045,0.0004810221,0.0004408474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003161595,"about_ca_system_score_gemma":0.0002356938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008589526,"about_ca_topic_score_gemma":0.002080501,"domain_scores_codex":[0.9998273,0.00001481192,0.0000273995,0.00004275096,0.00006134969,0.00002639712],"domain_scores_gemma":[0.9998863,0.00002960572,0.00003609782,0.00001192646,0.00000719185,0.00002891127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000467816,0.00001226213,0.0002997155,0.00002509228,0.00001093912,0.000136401,0.00000918463,0.0002126223,0.9981418,0.00009044785,0.00003577577,0.000979024],"study_design_scores_gemma":[0.00001074754,0.00007079125,0.003189429,0.000003008939,0.00002612005,0.0005271632,0.00001627607,0.001796459,0.9929351,0.00004895269,0.001371701,0.000004197294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865501,0.0005019176,0.008873972,0.00009587226,0.00002060401,0.00006272232,0.001946863,0.0003357545,0.00161226],"genre_scores_gemma":[0.9923761,0.0002546549,0.004908365,0.00004483939,0.000002096191,0.00002964947,0.001005649,0.00005166656,0.001326991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001544912,"threshold_uncertainty_score":0.005168259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01051267639227084,"score_gpt":0.2585402280112201,"score_spread":0.2480275516189492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}