{"id":"W2190996647","doi":"10.1016/j.jmb.2015.12.002","title":"Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biological and Environmental Research; Basic Energy Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Leukemia and Lymphoma Society of Canada; U.S. Public Health Service; University of Hawai'i; Leukemia and Lymphoma Society","keywords":"Pharmacogenetics; T-cell receptor; Computational biology; Antibody; Chemistry; Biology; Genetics; Biophysics; Molecular biology; Genotype; Gene; T cell; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133538,0.0003331549,0.0002622108,0.0002239525,0.0004026253,0.000373576,0.0006665858,0.0008632034,0.003736654],"category_scores_gemma":[0.0002960618,0.0002164532,0.0003366646,0.0001265903,0.0002179006,0.0002245975,0.0002667588,0.001004461,0.0007699354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007856116,"about_ca_system_score_gemma":0.0004710448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009787453,"about_ca_topic_score_gemma":0.0007997745,"domain_scores_codex":[0.9998616,0.00002653162,0.000005106556,0.00003038084,0.00003991514,0.00003646299],"domain_scores_gemma":[0.9998919,0.00002451364,0.00001792452,0.00001088697,0.00001746942,0.00003725683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000846541,0.0002671743,0.00208801,0.00008666521,0.00006245762,0.003692568,0.00009760958,0.01276006,0.9371549,0.01968122,0.003134908,0.02012776],"study_design_scores_gemma":[0.0004216709,0.00213054,0.005763086,0.0000322213,0.0001510752,0.005235362,0.00009347161,0.08676417,0.8478689,0.007059828,0.04440525,0.00007442924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9278961,0.00125872,0.03814768,0.002029627,0.0004886881,0.0001527859,0.0005260115,0.0005361926,0.02896415],"genre_scores_gemma":[0.9843939,0.0002006723,0.009204353,0.0004867327,0.00003074899,0.00002623359,0.0003226795,0.00002289128,0.005311776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003736654,"threshold_uncertainty_score":0.01250035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122633768303827,"score_gpt":0.3608107842871544,"score_spread":0.3395844466041161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}