{"id":"W2191219754","doi":"10.1016/s1470-2045(15)00465-9","title":"Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":410,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; McMaster University; Juravinski Cancer Centre","funders":"Janssen Research and Development","keywords":"Bendamustine; Medicine; Rituximab; Ibrutinib; Internal medicine; Chronic lymphocytic leukemia; Placebo; Oncology; Gastroenterology; Lymphoma; Leukemia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002799059,0.001035201,0.003595498,0.0003859696,0.0004893611,0.0001839062,0.0006850158,0.0003925034,0.00006795859],"category_scores_gemma":[0.0005225533,0.0005919786,0.0001304711,0.0009380582,0.001437531,0.000188744,0.0003947728,0.0004562396,0.00003790413],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03579395,"about_ca_system_score_gemma":0.04589505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002445562,"about_ca_topic_score_gemma":0.004994927,"domain_scores_codex":[0.9939083,0.0006927122,0.001150272,0.001451592,0.0008639209,0.001933209],"domain_scores_gemma":[0.9937594,0.002371019,0.0006060019,0.001485323,0.0007479307,0.001030359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9775483,0.004635626,0.0006297493,0.001226355,0.001649132,0.002001024,0.003070029,0.0002571126,0.0001017214,0.0001027447,0.002020011,0.00675817],"study_design_scores_gemma":[0.866789,0.04515382,0.0001285861,0.0004681236,0.00267764,0.008700125,0.001665351,0.06949015,0.0003478563,0.00002738809,0.00387004,0.0006819614],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788823,0.002192649,0.0002285258,0.0009928191,0.0001428096,0.01585198,0.00008431864,0.000352688,0.001271922],"genre_scores_gemma":[0.9916122,0.0003269653,0.001722249,0.0005654421,0.0008028185,0.003102412,0.0002519831,0.0002084521,0.001407457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1107594,"threshold_uncertainty_score":0.9996532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1312919578447798,"score_gpt":0.3850341185845375,"score_spread":0.2537421607397577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}