{"id":"W2191219754","doi":"10.1016/s1470-2045(15)00465-9","title":"Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":410,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; McMaster University; Juravinski Cancer Centre","funders":"Janssen Research and Development","keywords":"Bendamustine; Medicine; Rituximab; Ibrutinib; Internal medicine; Chronic lymphocytic leukemia; Placebo; Oncology; Gastroenterology; Lymphoma; Leukemia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002410678,0.002802495,0.005522549,0.000853355,0.0006188602,0.001625436,0.001846992,0.003035712,0.007239156],"category_scores_gemma":[0.002196155,0.001553343,0.003113706,0.0006803245,0.002195848,0.001872978,0.0006992289,0.003790539,0.001712272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001211391,"about_ca_system_score_gemma":0.001136711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002112722,"about_ca_topic_score_gemma":0.002814974,"domain_scores_codex":[0.9989029,0.0005541773,0.00007125409,0.0002054966,0.00008288716,0.0001832764],"domain_scores_gemma":[0.9988299,0.0004020565,0.0002229839,0.0001050896,0.00006704393,0.0003728553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9921428,0.002501667,0.0000866073,0.0002512972,0.0005324208,0.00001164828,0.00002072702,0.0001090599,0.001175599,0.00002935213,0.0001309648,0.003007716],"study_design_scores_gemma":[0.9634883,0.0353038,0.0003890404,0.00001514474,0.0003121189,0.000008384292,0.00001066099,0.0001204016,0.0001351081,0.00005025933,0.0001575171,0.000009410374],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848744,0.007065066,0.0007339272,0.0005491765,0.001044239,0.00275928,0.0008293504,0.0001810419,0.001963501],"genre_scores_gemma":[0.9819409,0.00438544,0.001595566,0.001064877,0.0009457949,0.004092555,0.0009682103,0.00005753296,0.004949119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007239156,"threshold_uncertainty_score":0.02421743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1312919578447798,"score_gpt":0.3850341185845375,"score_spread":0.2537421607397577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}