{"id":"W2191244341","doi":"10.1242/dev.125385","title":"Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFβ and Wnt signaling","year":2015,"lang":"en","type":"article","venue":"Development","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Harvard Stem Cell Institute","keywords":"Biology; Wnt signaling pathway; Cell biology; Embryonic stem cell; Retina; Population; Stem cell; Transplantation; Anatomy; Neuroscience; Signal transduction; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001489635,0.0001330211,0.0001709864,0.00004087529,0.00004820677,0.000008993775,0.00005951961,0.0000927233,0.00001023532],"category_scores_gemma":[0.00001573594,0.0001269398,0.00002934209,0.0000637819,0.00006231291,0.000005851488,0.00008000805,0.00003657075,0.000002515504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003009073,"about_ca_system_score_gemma":0.000117778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001618162,"about_ca_topic_score_gemma":0.00001474263,"domain_scores_codex":[0.9991167,0.00003420609,0.0003235775,0.0002106772,0.0001867425,0.0001280986],"domain_scores_gemma":[0.9995209,0.00001243592,0.0001792023,0.00008694099,0.0001456938,0.00005485419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005814695,0.00006480998,0.002897135,0.00008818556,0.00004830507,9.981538e-7,0.00232897,0.00006830465,0.9926865,0.00004622903,0.0001449757,0.001567462],"study_design_scores_gemma":[0.0006755991,0.0001541996,0.0006419283,0.00004661156,0.00001072226,0.000001051113,0.0006833293,0.00001967157,0.9961712,0.0001185262,0.001318468,0.0001586453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980944,0.0003172353,0.001081568,0.00001359,0.00008996407,0.0001814335,0.00000201226,0.00000679229,0.000212997],"genre_scores_gemma":[0.9974717,0.00006006574,0.002058279,0.00002522565,0.00001646872,0.00001140973,0.0001364219,0.00001223944,0.000208117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003484771,"threshold_uncertainty_score":0.5176454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544821091065945,"score_gpt":0.239087683641562,"score_spread":0.2236394727309025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}