{"id":"W2191244341","doi":"10.1242/dev.125385","title":"Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFβ and Wnt signaling","year":2015,"lang":"en","type":"article","venue":"Development","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Harvard Stem Cell Institute","keywords":"Biology; Wnt signaling pathway; Cell biology; Embryonic stem cell; Retina; Population; Stem cell; Transplantation; Anatomy; Neuroscience; Signal transduction; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008169535,0.0002077026,0.0001489972,0.0001154413,0.00006734088,0.0001502242,0.0000912288,0.00008641291,0.0006777999],"category_scores_gemma":[0.00004471812,0.00009667108,0.0001706815,0.0000998625,0.0001044328,0.00004752549,0.0001095438,0.0001624186,0.0002873218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001193632,"about_ca_system_score_gemma":0.0002068283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005721197,"about_ca_topic_score_gemma":0.001012288,"domain_scores_codex":[0.999935,0.000005355092,0.00001043771,0.00001368227,0.00002506203,0.00001040868],"domain_scores_gemma":[0.999976,0.000003587604,0.000005631694,0.000003435538,0.000004694798,0.000006683403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003135825,0.000009368189,0.0001598774,0.00003096881,0.00000249915,0.00003937721,0.0000135967,0.0000328129,0.9979205,0.00008336926,0.00003448326,0.001641807],"study_design_scores_gemma":[0.00000643736,0.00007200593,0.001450334,0.000004121117,0.000007878498,0.000088894,0.000009369753,0.0003628927,0.9929205,0.00001539818,0.005061013,0.000001129858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840993,0.002441331,0.007065476,0.00007380085,0.00005307692,0.00009713529,0.000491387,0.0001289192,0.005549684],"genre_scores_gemma":[0.9855483,0.001940039,0.006164671,0.00005825763,0.00001274012,0.00007431082,0.0007100465,0.00002303087,0.005468648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006777999,"threshold_uncertainty_score":0.00226742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544821091065945,"score_gpt":0.239087683641562,"score_spread":0.2236394727309025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}