{"id":"W2191633664","doi":"10.7554/elife.09300","title":"Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; University of California, San Francisco; National Institute of Dental and Craniofacial Research; American Society for Engineering Education; Howard Hughes Medical Institute; National Defense Science and Engineering Graduate; U.S. Department of Defense; National Institutes of Health; National Science Foundation","keywords":"Receptor; Cell biology; Signal transduction; Cell; Cell surface receptor; SMAD; Cell signaling; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002713859,0.000100996,0.0002007313,0.0001419518,0.00004286371,0.00001407371,0.00005139384,0.00007656444,0.000244956],"category_scores_gemma":[0.001480886,0.00008832359,0.00002019625,0.0004057332,0.00004547081,0.00004810681,0.00008578278,0.00008693778,0.00009241308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005284226,"about_ca_system_score_gemma":0.0001060508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001276297,"about_ca_topic_score_gemma":0.000003371257,"domain_scores_codex":[0.9987482,0.00005938225,0.0002485354,0.0002241014,0.0005733995,0.00014633],"domain_scores_gemma":[0.9987321,0.00004239897,0.00007163781,0.0001717644,0.0006794127,0.0003026886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001130955,0.00003653406,0.03270743,0.00003657075,0.0000107712,0.000003186479,0.0006045557,0.0001058859,0.9618651,0.000005563368,0.001818264,0.002693089],"study_design_scores_gemma":[0.0008583296,0.0003342199,0.00355437,0.00009751625,0.00002444192,0.000002725709,0.0003338196,0.004007535,0.9862984,0.000001690147,0.004382401,0.0001045452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96623,0.0001100895,0.03234294,0.0006362818,0.0001417625,0.0004144806,0.000004282167,0.00004150613,0.00007867419],"genre_scores_gemma":[0.9914932,0.00006339324,0.007494582,0.0001446388,0.0001491656,0.000003700182,0.0002022908,0.00003683538,0.0004121808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02915306,"threshold_uncertainty_score":0.3601731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02436527345790334,"score_gpt":0.2824840344276023,"score_spread":0.258118760969699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}