{"id":"W2191633664","doi":"10.7554/elife.09300","title":"Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; University of California, San Francisco; National Institute of Dental and Craniofacial Research; American Society for Engineering Education; Howard Hughes Medical Institute; National Defense Science and Engineering Graduate; U.S. Department of Defense; National Institutes of Health; National Science Foundation","keywords":"Receptor; Cell biology; Signal transduction; Cell; Cell surface receptor; SMAD; Cell signaling; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000204404,0.0001819945,0.0002020125,0.0002329343,0.0002161389,0.0006550957,0.0003481287,0.0003192498,0.0008232543],"category_scores_gemma":[0.000264156,0.0002843994,0.0002167479,0.0001447591,0.000374972,0.0005229339,0.0003970134,0.0006597149,0.0002798025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006071884,"about_ca_system_score_gemma":0.0002136393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004323678,"about_ca_topic_score_gemma":0.000921111,"domain_scores_codex":[0.9997372,0.00002865682,0.00001680303,0.00006960604,0.00008152585,0.00006619502],"domain_scores_gemma":[0.9998223,0.00003398371,0.00006712219,0.00002989423,0.00001773845,0.00002900237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002360625,0.000005876196,0.0001985166,0.000008383982,0.000002030923,0.00002109364,0.00001119005,0.00008955699,0.9984673,0.0002322081,0.00001167655,0.0009286146],"study_design_scores_gemma":[0.00001488618,0.00005779446,0.007704756,0.000005458404,0.000007918306,0.0001834714,0.0000768215,0.004469423,0.9862056,0.0002555174,0.001011842,0.000006502813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988225,0.0007327597,0.009366676,0.0001167449,0.00001328825,0.00001358203,0.00005995361,0.00006255522,0.001409437],"genre_scores_gemma":[0.9953812,0.0004238211,0.003124973,0.00004084389,0.000005766361,0.00001894262,0.00006162375,0.00001654797,0.0009262381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008232543,"threshold_uncertainty_score":0.004405499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02436527345790334,"score_gpt":0.2824840344276023,"score_spread":0.258118760969699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}