{"id":"W2191719293","doi":"10.1016/j.molcel.2015.10.039","title":"EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation","year":2015,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Chromatin; Biology; Enhancer; ChIA-PET; Promoter; Histone H3; Histone; Nucleosome; Cell biology; Transcription (linguistics); Acetylation; Histone code; Histone-modifying enzymes; Pioneer factor; Transcription coregulator; Molecular biology; Chromatin remodeling; Transcription factor; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003397488,0.0002966563,0.0003118876,0.000479656,0.0004746183,0.0006757859,0.000576501,0.0004797195,0.005306099],"category_scores_gemma":[0.0003866221,0.0005206021,0.0003963023,0.000351911,0.0005649665,0.0007674196,0.0007598755,0.001253604,0.001924055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007192923,"about_ca_system_score_gemma":0.0004174465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001382252,"about_ca_topic_score_gemma":0.00169733,"domain_scores_codex":[0.9997407,0.00002309997,0.00001045838,0.00005964499,0.00006548977,0.0001005592],"domain_scores_gemma":[0.9996837,0.0001045358,0.00003416291,0.00005870008,0.00004472755,0.00007410202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003906421,0.00002600975,0.0003604699,0.00002276665,0.000006000339,0.00009112542,0.00003144297,0.0000898457,0.9958225,0.0004320699,0.00009351674,0.00263344],"study_design_scores_gemma":[0.0000192804,0.0000498261,0.00409361,0.00000260915,0.000004904068,0.00009918783,0.00003409725,0.0003406939,0.9940357,0.0002533091,0.001063418,0.000003228831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706662,0.001702858,0.02016259,0.0003324763,0.0000841232,0.00003738605,0.0003615058,0.0002692759,0.00638348],"genre_scores_gemma":[0.9829671,0.0005157545,0.003843796,0.0002088962,0.00003629137,0.00002813311,0.0005929216,0.0001839653,0.01162305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005306099,"threshold_uncertainty_score":0.01775068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003846120310723142,"score_gpt":0.1928419872073431,"score_spread":0.18899586689662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}