{"id":"W2191719293","doi":"10.1016/j.molcel.2015.10.039","title":"EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation","year":2015,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Chromatin; Biology; Enhancer; ChIA-PET; Promoter; Histone H3; Histone; Nucleosome; Cell biology; Transcription (linguistics); Acetylation; Histone code; Histone-modifying enzymes; Pioneer factor; Transcription coregulator; Molecular biology; Chromatin remodeling; Transcription factor; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006631839,0.0001295749,0.00008621633,0.00002844388,0.00005300788,0.00003244367,0.0000993679,0.0001058985,0.000001353948],"category_scores_gemma":[0.00001390455,0.0001397144,0.00003643208,0.00004652209,0.00003261946,0.000003560001,0.0001150581,0.00005476803,0.000004963319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003337999,"about_ca_system_score_gemma":0.00004923814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002165213,"about_ca_topic_score_gemma":0.00001010646,"domain_scores_codex":[0.9993038,0.00002740539,0.0001203818,0.0002835555,0.0000960966,0.0001687902],"domain_scores_gemma":[0.9995465,0.000001343958,0.00005872551,0.0002282225,0.00004847029,0.0001167823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002409057,0.00002272448,0.0002725471,0.00002830514,0.00001768489,0.000007837935,0.0001491366,0.0003425757,0.9984262,0.000006727722,0.00003713313,0.0006650208],"study_design_scores_gemma":[0.0005368653,0.0001152632,0.000410936,0.00000632438,0.00001145898,0.00001123494,0.00006077607,0.0003677776,0.997595,0.00009391496,0.0006178858,0.0001726048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990428,0.000463553,0.007892506,0.0000720735,0.00005902991,0.0001440143,0.000001588024,0.00001054008,0.0009286986],"genre_scores_gemma":[0.9943999,0.00005521512,0.005062575,0.0001112515,0.0000441322,0.00001243188,0.00006796319,0.00002806654,0.0002184408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003971928,"threshold_uncertainty_score":0.5697389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003846120310723142,"score_gpt":0.1928419872073431,"score_spread":0.18899586689662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}