{"id":"W2191790139","doi":"10.1016/j.cell.2015.11.045","title":"Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":445,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Center for Advancing Translational Sciences; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Biology; Flux (metallurgy); Cholesterol; Downregulation and upregulation; Biosynthesis; Reprogramming; Cell biology; Innate immune system; Metabolic pathway; Signal transduction; Biochemistry; Cholesterol synthesis; Limiting; Reverse cholesterol transport; Metabolism; Cell; Lipoprotein; Enzyme; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004527946,0.00016366,0.0002017266,0.00008842568,0.0001266238,0.00002776443,0.0002184028,0.0001785969,0.0007840251],"category_scores_gemma":[0.0002555148,0.0001446347,0.00006557436,0.00007716024,0.00009905292,0.00005460326,0.00007982923,0.0003357392,0.005994894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004016163,"about_ca_system_score_gemma":0.00007593325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002906467,"about_ca_topic_score_gemma":0.000004490701,"domain_scores_codex":[0.9987784,0.000414113,0.0002168352,0.0002168579,0.00003065763,0.0003431059],"domain_scores_gemma":[0.9993048,0.0002486415,0.00007367085,0.0002448137,0.00009245715,0.00003557471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002788047,0.00006956784,0.00006303996,0.00001228538,0.00002880568,0.00003831557,0.001164075,0.000007677768,0.991731,0.00001952651,0.004040822,0.002546081],"study_design_scores_gemma":[0.0006122699,0.0003465067,0.0000704015,0.00003982064,0.00002342096,0.0003435688,0.001241761,0.00000641113,0.8887695,0.00001429529,0.1083667,0.0001653733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789655,0.003128053,0.0000490101,0.0001071972,0.00115812,0.0001073175,0.000004616308,0.0001139142,0.01636633],"genre_scores_gemma":[0.9656206,0.00001937487,0.00006126461,0.0002495568,0.00004616706,0.000003393437,0.0000316222,0.00002524673,0.03394273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1043258,"threshold_uncertainty_score":0.9947791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0311323856374542,"score_gpt":0.2438397605830486,"score_spread":0.2127073749455944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}