{"id":"W2191790139","doi":"10.1016/j.cell.2015.11.045","title":"Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":445,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Center for Advancing Translational Sciences; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Biology; Flux (metallurgy); Cholesterol; Downregulation and upregulation; Biosynthesis; Reprogramming; Cell biology; Innate immune system; Metabolic pathway; Signal transduction; Biochemistry; Cholesterol synthesis; Limiting; Reverse cholesterol transport; Metabolism; Cell; Lipoprotein; Enzyme; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000433022,0.0003425603,0.0003655209,0.0002377985,0.0002303799,0.0008240019,0.0002727729,0.0004249563,0.001501071],"category_scores_gemma":[0.0005172084,0.0001639639,0.0002328691,0.0001751831,0.0003706012,0.0004683917,0.0005786573,0.0008837096,0.0005525782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000535087,"about_ca_system_score_gemma":0.0003144257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002130049,"about_ca_topic_score_gemma":0.0004310669,"domain_scores_codex":[0.9997061,0.0000502171,0.00001649154,0.00005400085,0.00007785472,0.00009534649],"domain_scores_gemma":[0.9996806,0.0001044042,0.00005624785,0.00007109872,0.00003003824,0.00005757612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002107792,0.00002693924,0.0003841539,0.00002432449,0.000005045068,0.00005863188,0.00001909453,0.0001155222,0.9952642,0.001521669,0.0001289259,0.002240693],"study_design_scores_gemma":[0.0000151399,0.00005102091,0.0003651595,0.000004299082,0.000005119582,0.00005242151,0.00002795057,0.00136551,0.9955716,0.0008163934,0.001720247,0.000005085106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793693,0.0009719154,0.01349146,0.000649464,0.000200172,0.00004222671,0.0002552203,0.0003525252,0.004667544],"genre_scores_gemma":[0.9955918,0.0002548768,0.002338198,0.000128646,0.00002681925,0.00002441054,0.00009368634,0.00004927135,0.001492369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501071,"threshold_uncertainty_score":0.005021632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0311323856374542,"score_gpt":0.2438397605830486,"score_spread":0.2127073749455944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}