{"id":"W2191824595","doi":"10.3390/fermentation1010113","title":"Antisense-RNA-Mediated Gene Downregulation in Clostridium pasteurianum","year":2015,"lang":"en","type":"article","venue":"Fermentation","topic":"Microbial Fuel Cells and Bioremediation","field":"Environmental Science","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centurion Biofuels (Canada); University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gene knockdown; Biology; Antisense RNA; Hydrogenase; Gene; Gene expression; Plasmid; Promoter; Downregulation and upregulation; Regulation of gene expression; Molecular biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000283248,0.00008870928,0.0000765911,0.00004962421,0.0000376202,0.00002619608,0.00006162278,0.00006073197,0.0005535285],"category_scores_gemma":[0.0000322394,0.00008588226,0.00001885907,0.0002830662,0.00003220823,0.0002687961,0.00003583515,0.00006171364,0.0009641829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601279,"about_ca_system_score_gemma":0.00001370783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000324532,"about_ca_topic_score_gemma":0.0001662386,"domain_scores_codex":[0.9990945,0.00007947462,0.0002158718,0.0002001569,0.000245377,0.0001645764],"domain_scores_gemma":[0.9997178,0.00001221149,0.00008643425,0.00009463369,0.00001085247,0.00007803192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004279882,0.00005651856,0.03257859,0.000003335588,0.000001620552,0.000005394851,0.0006448883,0.0009652037,0.9584262,0.000006582572,0.004536601,0.002732247],"study_design_scores_gemma":[0.002196471,0.000134416,0.645924,0.00001088356,0.00001124588,0.000006741936,0.0003227839,0.004253456,0.342301,0.0004592604,0.004085989,0.0002936806],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99603,0.00001168793,0.0001817103,0.0002999725,0.0002733303,0.000262056,0.000009993424,0.00002882489,0.002902386],"genre_scores_gemma":[0.9983681,0.00001940045,0.0005977395,0.0001420068,0.00008615853,0.000008091594,0.0004307306,0.000008321385,0.0003394939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6161252,"threshold_uncertainty_score":0.9998137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777252621691261,"score_gpt":0.2225082396235271,"score_spread":0.2047357134066145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}